Porcine Coronary Artery Endothelial: PCAEC (Cryovial)

半岛bd体育手机客户端 说明

一般描述

Arterial endothelial cells play critical roles in cardiac homeostasis, and insults to the endothelial cells have been linked to a variety of vascular diseases. Porcine artery endothelial cells provide a useful tool to study artery endothelial function and metabolism.PCAEC from Cell Applications, Inc. have been used to investigate a new mechanism of obesity-associated vascular disease by demonstrating that resistin, an adipocyte-derived cytokine implemented in insulin resistance and diabetes, can cause endothelial dysfunction in coronary arteries through oxidative stress and down-regulation of NO synthase (Kougias, 2005). Conversely, secretoneurin was shown to activate expression of NO synthase and calmodulin, leading to endothelial relaxation (Chan, 2011). PCAEC were also used in adhesion and transmigration experiments in a study investigating anti-inflammatory, cardioprotective effects of a novel adenosine-lidocaine drug formulation (Shi, 2012).

细胞系来源

Artery

应用

cardiovascular function, angiogenesis, vascular biology, regulation of coronary blood flow, cardiac functions, effects of vaso-dilators, coagulation, fibrinolysis, vessel wall tone, cytokine production

组分

Porcine Endothelial Cell Growth Medium that contains 10% FBS and 10% DMSO

制备说明

• 2nd passage, >500,000 cells in Porcine Endothelial Cell Growth Medium that contains 10% FBS and 10% DMSO
• Can be cultured at least 12 doublings

传代培养常规

Please refer to the PCAEC Culture Protocol.

基本信息

NACRES

NA.81

半岛bd体育手机客户端 性质

质量水平	100
生物来源	Porcine coronary artery
包装	pkg of 500,000 cells
生长模式	Adherent
核型	2n = 38
形态学	Endothelial
technique(s)	cell culture | mammalian: suitable
相关疾病	cardiovascular diseases
运输	dry ice
储存温度	?196℃

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable