TopFluor^?PI(3,4,5)P3

半岛bd体育手机客户端 说明

一般描述

Phosphatidylinositol-3,4,5-trisphosphate (PI(3,4,5)P3) is an inadequate phospholipid present on the inner leaflet of the plasma membrane.
PI(3,4,5)P3 (diacylphosphatidylinositol-3,4,5-trisphosphate) is restricted to the cell membrane of inner leaflet. TopFluor^?PI(3,4,5)P3 is a fluorescently labeled-phosphoinositide derivative containing saturated acyl chain.

生化/生理作用

Phosphatidylinositol-3,4,5-trisphosphate (PI(3,4,5)P3) plays a key role in inducing the cluster of Syntaxin1A at presynaptic terminals. It also regulates the activity protein kinase B/Akt.
PI(3,4,5)P3 (diacylphosphatidylinositol-3,4,5-trisphosphate) serves as a substrate for PTEN (phosphatase and tensin homolog), a tumor suppressor protein. It has binding affinity towards the active site of phosphatase domain. TopFluor^?PI(3,4,5)P3 might be useful in monitoring protein induced phosphoinositide clustering. This product is considered photostable than other fluorophores.

包装

2 mL Amber Serum Vial with Stopper and Crimp Cap (810189P-50ug)

法律信息

TopFluor is a registered trademark of Avanti Polar Lipids, Inc.

基本信息

经验(实验)分子式	C56H108BF2N7O23P4
分子量	1420.19
NACRES	NA.25

半岛bd体育手机客户端 性质

测定	>99% (TLC)
形式	powder
包装	pkg of 1 × 50 μg (with stopper and crimp cap (810189P-50ug))
manufacturer/tradename	Avanti Polar Lipids 810189P
运输	dry ice
储存温度	?20℃

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable