VPC 32179 (R)

半岛bd体育手机客户端 说明

一般描述

VPC 32179 is devoid of agonist activity at the human LPA2 and LPA3 receptors and behaves as a competitive antagonist at the LPA3 receptor. However, VPC 32179 has been found to have partial agonist activity in a cell migration assay; this is most likely due to activity at the LPA1 receptor.

应用

VPC 32179 (R) has been used:

• to examine the roles of lysophosphatidic acid (LPA) receptor subtypes in related adhesion focal tyrosine kinase (RAFTK) activation
• as a LPA3 receptor antagonist to inhibit LPA-induced protein kinase C (PKC) activity in cultured muscle cells
• as a LPA1 competitive antagonist to block LPA-induced proliferation of mast cells

生化/生理作用

VPC 32179 exhibits partial agonist activity in cell migration assay, which is due to the activity at lysophosphatidic acid 1 (LPA1) receptor. It lacks agonist activity at the human LPA2 and LPA3 receptors. VPC 32179 exhibits competitive antagonistic activity at the LPA3 receptor.

包装

5 mL Amber Glass Screw Cap Vial (857350P-1mg)

基本信息

经验(实验)分子式	C33H54N3O6P
分子量	619.77
NACRES	NA.25

半岛bd体育手机客户端 性质

测定	>99% (TLC)
形式	powder
包装	pkg of 1 × 1 mg (857350P-1mg)
manufacturer/tradename	Avanti Polar Lipids 857350P
运输	dry ice
储存温度	?20℃
SMILES string	O=C(CCCCCCC/C=C\CCCCCCCC)N[C@H](CC1=CC=C(OCC2=CC=CC=N2)C=C1)COP(O)([O-])=O.[NH4+]

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3