7-dehydrocholesterol-d7

半岛bd体育手机客户端 说明

一般描述

7-dehydrocholesterol (7-DHC) is a cholesterol precursor and is localized in basal epidermal keratinocytes. 7DHC on photolysis in the presence of ultraviolet light B generates previtamin D3. The enzyme 7-dehydrocholesterol reductase (DHCR7) catalyzes the reduction of C(7-8) double bond of 7-DHC to cholesterol. 7-dehydrocholesterol-d7 is a deuterated derivative of 7-dehydrocholesterol.

应用

7-dehydrocholesterol-d7 has been used:

• as an internal standard: to spikeChlamydomonasCC-125 lipid extract for mass spectroscopy analysis
• in liquid chromatography–mass spectrometry (LC-MS) for cultured cells oxysterol analysis
• to treat and label SRD-1 cell (chinese hamster ovary (CHO) mutant cell-line) for gas chromatography/mass spectrometry (GC/MS) analysis

生化/生理作用

7-Dehydrocholesterol (7-DHC) is used as a precursor for microbial vitamin D3 production. Impairment of 7-dehydrocholesterol reductase (DHCR7) functionality leads to 7-DHC accumulation and is implicated in Smith-Lemli-Opitz syndrome (SLOS).

包装

5 mL Amber Glass Screw Cap Vial (700116P-1mg)

基本信息

经验(实验)分子式	C27H37D7O
分子量	391.68
NACRES	NA.25

半岛bd体育手机客户端 性质

测定	>99% (TLC)
形式	powder
包装	pkg of 1 × 1 mg (700116P-1mg)
manufacturer/tradename	Avanti Polar Lipids 700116P
运输	dry ice
储存温度	?70℃

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable