16:0 Cardiolipin

半岛bd体育手机客户端 说明

一般描述

Cardiolipins are anionic teraacylphospholipid, present in inner mitochondrial membrane eukaryotic cells and bacterial cytoplasmic membranes. 16:0 cardiolipin is synthesized byde novopathway. 16:0 Cardiolipin binds to myeloid differentiation protein 2 (MD2).
Cardiolipin is a unique phospholipid located in the inner mitochondrial membrane, which makes up to 20% of total lipids. It is a non-bilayer anionic phospholipid, which has four acyl chains and small headgroup.
The 16:0 number indicates the fatty acyl substituents attached to the carbons of glycerol.

应用

16:0 Cardiolipin might be suitable to assay mitochondrial fractions for CL-specific phospholipase activity.

生化/生理作用

Cardiolipin (CL) plays a key role in coordinating energy metabolism in eukaryotes. Metabolic defect in the CL pathway is implicated in dilated cardiomyopathy. CL is essential for mitochondrial functions and apoptosis. Alternations in CL content and their acyl chain composition, contributes to mitochondrial dysfunction in various pathological conditions.
Cardiolipin regulates the dynamic organization of membranes and cell division. It is involved in proton uptake pathway. Cardiolipin plays an important role in mitochondrial biogenesis, fusion and fission, respiration and protein import. It modulates cell wall biogenesis, vacuole homeostasis, aging, cell cycle and apoptosis.
Cardiolipin maintains the mitochondrial function, membrane potential and structural support for the inner mitochondrial membrane and proteins in it. Concentration and composition changes of cardiolipin have been implicated in pathological conditions including ischemia, hypothyroidism, aging, heart failure and cardioskeletal myopathy. The association of cardiolipin and cytochrome c determines the action of proteins involved in oxidative phosphorylation and apoptosis.

包装

5 mL Amber Glass Screw Cap Vial (710333P-25mg)

基本信息

经验(实验)分子式	C73H140Na2O17P2
分子量	1397.81
NACRES	NA.25

半岛bd体育手机客户端 性质

测定	>99% (TLC)
形式	powder
包装	pkg of 1 × 25 mg (710333P-25mg)
manufacturer/tradename	Avanti Polar Lipids 710333P
运输	dry ice
储存温度	?20℃

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	755.6 - 820.4 °F
闪点(C)	402 - 438 ℃