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位置: 首页> 品牌> Sigma-Aldrich> Anti-Peroxiredoxin 6 (C-terminal) antibody produced in rabbit

Anti-Peroxiredoxin 6 (C-terminal) antibody produced in rabbit

品牌
Sigma-Aldrich
货号
P0058
规格纯度
~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution
价格
5045.46 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
Anti-Peroxiredoxin 6 (C-terminal) antibody produced in rabbit
Anti-Acidic calcium-independent phospholipase A2
Anti-Antioxidant protein 2
Anti-1-Cys peroxiredoxin
Anti-Non-selenium glutathione peroxidase, AOP2
Anti-PRDX6
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

PRDX6 (peroxiredoxin 6) is a mammalian peroxidase belonging to the 1-Cys Prdx family, meaning it has 1-Cys at position 47 (Cys47). This protein is localized to cytoplasm, lysosomes, mitochondria, endoplasmic reticulum (ER) and plasma membrane. It is a homodimeric protein which is especially observed in mammalian lungs.?

应用

Anti-Peroxiredoxin 6 (C-terminal) antibody produced in rabbit has been used for Western Blotting.

生化/生理作用

PRDX6 (peroxiredoxin 6) has both peroxidase and phospholipase A2 (PLA2) activities and thus, is a bifunctional protein. In liver, as a peroxidase it confers protection against damage from ROS (reactive oxygen species) during ischemia-reperfusion injury. As a PLA2 it is involved in lung surfactant metabolism. It is also essential for normal nicotinamide adenine dinucleotide phosphate-oxidase activity. In the livers of donors after brain death (DBD), this protein suppresses ischemia- and hypoxia-induced liver damage, and its expression is controlled by NF-κB (nuclear factor). In human and mouse neuronal cells, the delivery of PRDX6 protein leads to delay or suppression in oxidative stress-induced neuronal cell death.
Peroxiredoxin 6 contains a single redox-active cysteine and uses glutathione to catalyze the reduction of H2O2 and other organic peroxides. Overexpression of peroxiredoxin 6 in cells protects them against oxidative damage, whereas knockdown of this enzyme results in oxidative stress and apoptosis. The phospholipase A2 activity plays an important role in surfactant homeostasis. Peroxiredoxin 6 is a major antioxidant enzyme which functions in antioxidant defense and lung phospholipid metabolism.

外形

0.01M 磷酸缓冲盐溶液,pH 7.4,含 15mM 叠氮化钠。

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 200
偶联物 unconjugated
抗体形式 affinity isolated antibody
antibody product type primary antibodies
克隆 polyclonal
形式 buffered aqueous solution
分子量 antigen ~25 kDa
species reactivity mouse, human, rat
浓度 ~1.0 mg/mL
technique(s) immunoprecipitation (IP): 2-5 μg using whole extract of mouse brain
western blot: 0.5-1.0 μg/mL using whole extract of human HeLa cells.
western blot: 1-2 μg/mL using whole extract of rat brain
UniProt登记号 P30041
运输 dry ice
储存温度 ?20℃
Gene Information human ... PRDX6(9588)
mouse ... Prdx6(11758)
rat ... Prdx6(94167)

安全信息

储存分类代码 12 - Non Combustible Liquids
闪点(F) Not applicable
闪点(C) Not applicable
个人防护装备 Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Sigma-Aldrich

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