25-hydroxycholesterol-3-sulfate

半岛bd体育手机客户端 说明

一般描述

25-hydroxycholesterol-3-sulfate (25OHC3S) is a nuclear oxysterol. It accumulates in hepatocyte nuclei upon steroidogenic acute regulatory protein (STARD1) overexpression.

应用

25-hydroxycholesterol-3-sulfate has been used to induce anti-inflammatory responses and understand its effect on lymphocyte migration. It has also been used as an oxysterol sulfate standard in mass spectroscopy and liquid chromatography methods.

生化/生理作用

25-hydroxycholesterol-3-sulfate (25OHC3S) is involved in lipid homeostasis in liver and is a lipid metabolism regulator. 25OHC3S acts on liver X receptor (LXR) and sterol regulatory element-binding protein (SREBP) and inhibits cholesterol synthesis by downregulating enzymes of the biosynthesis pathway in hepatocytes and macrophages. It also acts an agonist for peroxisome proliferator-activated receptor γ (PPAR-γ) and modulates the nuclear factor κ-light-chain-enhancer (NF-κB) based inflammatory response. 25OHC3S modulates tumor necrosis factor α (TNFα)-induced inflammatory response in hepatocytes.

包装

5 mL Amber Glass Screw Cap Vial (700017P-10mg)
5 mL Amber Glass Screw Cap Vial (700017P-5mg)

基本信息

经验(实验)分子式	C27H45NaO5S
分子量	504.70
NACRES	NA.25

半岛bd体育手机客户端 性质

测定	>99% (TLC)
形式	powder
包装	pkg of 1 × 10 mg (700017P-10mg) pkg of 1 × 5 mg (700017P-5mg)
manufacturer/tradename	Avanti Polar Lipids 700017P
运输	dry ice
储存温度	?20℃
SMILES string	[H][C@@]12[C@]([C@](CC[C@H](OS(=O)([O-])=O)C3)(C)C3=CC2)([H])CC[C@@]4(C)[C@@]1([H])CC[C@]4([H])[C@]([H])(C)CCCC(C)(O)C.[Na+]

安全信息

储存分类代码

13 - Non Combustible Solids