p53 human

半岛bd体育手机客户端 说明

一般描述

p53 protein is composed of an N-terminal domain with a transactivation domain and proline-rich region, a central core-DNA binding domain, and a C-terminal domain with tetramerization and regulatory domains. The TP53 gene which encodes for the p53 protein is mapped on the human chromosome at 17p13.1.

应用

p53 human has been used in dot blot.
Useful for the study of postranslational modification of p53, or protein-protein interaction studies.

生化/生理作用

p53 protein acts as a transcription factor that participates in regulating positively or negatively the expression of several responsive genes. It plays a role in regulating angiogenesis, cellular senescence, autophagy, cell survival, differentiation, and oxidative stress. Mutations in the TP53 gene lead to Li Fraumeni cancer syndrome.
p53 gene is highly conserved and expressed in normal tissues. It is the most commonly mutated gene in human cancer and more then 500 gene mutations have been described in various types of malignancies, hematologic as well as solid tumors. Intact p53 function is essential for the maintenance of the non-tumorogenic phenotype of cells. Thus, p53 plays a vital role in suppressing the development of cancer.
In addition, p53 was recently shown to induce differentiation of human embryonic stem cells. The effect is dependent on the DNA binding activity of p53.

物理属性

Histidine-tagged, full length human p53

外形

Supplied as a solution in 20 mM Tris-HCl, pH 8.0, 20% glycerol, 100 mM KCl, 0.2 mM EDTA, and 1 mM DTT.

基本信息

NACRES

NA.25

半岛bd体育手机客户端 性质

质量水平	200
生物来源	human
重组	expressed in baculovirus infectedSf21 cells
测定	≥90% (SDS-PAGE)
形式	aqueous solution
UniProt登记号	P04637
application(s)	genomic analysis
运输	dry ice
储存温度	?70℃
Gene Information	human ... TP53(7157)

安全信息

储存分类代码	12 - Non Combustible Liquids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable