半岛bd体育手机客户端 说明
一般描述
The P2X3 (purinergic receptor P2X 3) receptor is expressed in primary afferent neurons. It is a subtype of P2X receptors family of ligand-gated ion channels, activated by extracellular ATP (adenosine triphosphate).
免疫原
peptide (C)VEKQSTDSGAYSIGH corresponding to residues 383-397 of rat P2rx3.
应用
Anti-Purinergic Receptor P2X3 antibody has been used in immunohistochemistry.
生化/生理作用
The P2X3 (purinergic receptor P2X 3) plays a major role in the transmission of pain. Inducing P2X3 generates a desensitizing transient response and initiating P2X2/3 creates a relatively persistent response. P2X3 decreases the sympathetic tone in SH rats.
目标描述
The P2X3receptor is highly expressed on nociceptive sensory neurons in dorsal root ganglia (DRG) as a homomer or as a heteromer (P2X3/P2X2). ATP released from damaged cells activates the P2X3receptor to initiate nociceptive signals. Involvement of ATP in the mechanism of chronic pain contributes to P2X3receptor as a possible target for the development of pain therapeutics.
外形
Lyophilized from phosphate buffered saline, pH 7.4, containing 1% BSA and 0.05% sodium azide.
重悬
Reconstitute the lyophilized vial with 50 μL or 200 μL deionized water, depending on package size. Further dilutions should be made using a carrier protein such as BSA (1-3%).
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| NACRES | NA.41 |
半岛bd体育手机客户端 性质
| 生物来源 | rabbit |
| 质量水平 | 200 |
| 偶联物 | unconjugated |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | lyophilized powder |
| species reactivity | rat |
| technique(s) | immunohistochemistry: suitable using rat embryo DRG western blot: 1:200 using rat dorsal root ganglion (DRG) lysates |
| UniProt登记号 | P49654 |
| 运输 | dry ice |
| 储存温度 | ?20℃ |
| Gene Information | rat ... P2rx3(81739) |
安全信息
| 储存分类代码 | 13 - Non Combustible Solids |
| WGK | WGK 2 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
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