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位置: 首页> 品牌> Sigma-Aldrich> N-(5-Chloro-2-methoxyphenyl)-N′-(2-methylquinolin-4-yl)urea

PQ401

品牌
Sigma-Aldrich
CAS
196868-63-0
货号
P0113
规格纯度
≥98% (HPLC), powder
价格
2023.95 *本价格含增值税费
促销
服务
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数量
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半岛bd体育手机客户端 名称:
196868-63-0
PQ401
N-(5-Chloro-2-methoxyphenyl)-N′-(2-methylquinolin-4-yl)urea
IGF-1R Inhibitor II
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

应用

PQ401 has been used as:

  • an insulin growth factor-1 receptor (IGF-IR) inhibitor in H1299 cells to test its effect on migration suppression
  • a reference inhibitor in dose-response measurements studies
  • an IGF1R inhibitor in sirtuin 6 (SIRT6)-deficient cardiomyocytes to test its effect on hypertrophy inhibition

包装

10 mg in glass bottle

生化/生理作用

PQ401, a diaryl urea compound that serves as an anti-glioma agent.
PQ401 is an insulin growth factor-1 receptor (IGF-1R) inhibitor.

特点和优势

This compound is featured on the InsR page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

基本信息

经验(实验)分子式 C18H16ClN3O2
分子量 341.79
MDL编号 MFCD00160558
PubChem化学物质编号 24724567
NACRES NA.77

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥98% (HPLC)
形式 powder
颜色 white
溶解性 DMSO: >10 mg/mL
H2O: <2 mg/mL
储存温度 2-8℃
SMILES string COc1ccc(Cl)cc1NC(=O)Nc2cc(C)nc3ccccc23
InChI 1S/C18H16ClN3O2/c1-11-9-15(13-5-3-4-6-14(13)20-11)21-18(23)22-16-10-12(19)7-8-17(16)24-2/h3-10H,1-2H3,(H2,20,21,22,23)
InChI key YBLWOZUPHDKFOT-UHFFFAOYSA-N

安全信息

储存分类代码 6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable
个人防护装备 Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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