SPDP-dPEG^?₄-NHS ester

半岛bd体育手机客户端 说明

特点和优势

SPDP-dPEG^?₄-NHS ester has an amine-reactiveN-hydroxysuccinimide (NHS) ester at one end and a sulfhydryl-reactive 2-pyridyldithiol group at the opposite end. This has a single molecular weight PEG spacer arm, which confers greater water solubility to the crosslinker and linked proteins compared to crosslinkers having only hydrocarbon spacers. Protein aggregation and precipitation also are greatly reduced with SPDP-dPEG crosslinkers compared to crosslinkers that have only hydrocarbon spacers. dPEG spacer of specific length (23.1 ?) provides precise distance control between the SPDP moiety and the target molecule. Pyridyldithiol reagents produce disulfide-containing linkages that can be cleaved with reducing agents such as dithiothreitol (DTT). Crosslinking experiments with SPDP reagents are not limited to those involving proteins. Any of a variety of molecules with primary amines and sulfhydryl groups can be modified or crosslinked using SPDP reagents.

法律信息

Products Protected under U.S. Patents # 7,888,536 B2
dPEG is a registered trademark of Quanta BioDesign

基本信息

经验(实验)分子式	C23H33N3O9S2
分子量	559.65
MDL编号	MFCD13185001
PubChem化学物质编号	329823921
NACRES	NA.22

半岛bd体育手机客户端 性质

测定	>90%
形式	solid or viscous liquid
reaction suitability	reagent type: cross-linking reagent reactivity: amine reactive reagent type: cross-linking reagent reactivity: thiol reactive
聚合物结构设计	shape: linear functionality: heterobifunctional
运输	ambient
储存温度	?20℃
SMILES string	O=C(NCCOCCOCCOCCOCCC(ON1C(CCC1=O)=O)=O)CCSSC2=NC=CC=C2

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable