Naftifine Hydrochloride

半岛bd体育手机客户端 说明

应用

Naftifine is a synthetic, broad spectrum, antifungal agent and allylamine derivative. It is used topically to treat superficial dermatomycoses such as tinea pedis, tinea cruris, and tinea corporis.

包装

50, 500 mg in poly bottle

生化/生理作用

Naftifine is an allylamine compound that has antifungal and antimycotic activities. Naftifine inhibits fungal squalene epoxidase and prevents ergosterol biosynthesis. Naftifine also has antibiotic activity against Gram-positive and Gram-negative bacteria. It has demonstrated anti-inflammatory properties such as a reduction in superoxide production and a reduction in polymorphonuclear leukocyte chemotaxis/endothelial adhesion. Naftifine appears to interfere with sterol biosynthesis by inhibiting the squalene 2,3-epoxidase. This inhibition results in decreased amounts of ergosterol and an accumulation of squalene in the cells.
Allylamine compound that has antifungal and antimycotic activities. Naftifine inhibits fungal squalene epoxidase and prevents ergosterol biosynthesis. Naftifine also has antibiotic activity against Gram-positive and Gram-negative bacteria and has demonstrated anti-inflammatory properties.

其他说明

Keep container tightly closed in a dry and well-ventilated place.Light sensitive.

基本信息

经验(实验)分子式	C21H21N · HCl
分子量	323.86
MDL编号	MFCD00059047
PubChem化学物质编号	329818590

半岛bd体育手机客户端 性质

质量水平	200
测定	≥99%
形式	powder
溶解性	ethanol: soluble 50 mg/mL
抗生素抗菌谱	Gram-negative bacteria Gram-positive bacteria fungi yeast
作用机制	cell wall synthesis | interferes enzyme | inhibits
储存温度	2-8℃
SMILES string	Cl.CN(C\C=C\c1ccccc1)Cc2cccc3ccccc23
InChI	1S/C21H21N.ClH/c1-22(16-8-11-18-9-3-2-4-10-18)17-20-14-7-13-19-12-5-6-15-21(19)20;/h2-15H,16-17H2,1H3;1H/b11-8+;
InChI key	OLUNPKFOFGZHRT-YGCVIUNWSA-N

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	nwg
闪点(F)	Not applicable
闪点(C)	Not applicable