Curcumin, <i>Curcuma longa</i> L.-CAS 458-37-7-Calbiochem

半岛bd体育手机客户端名称：

458-37-7
Curcumin, Curcuma longaL.-CAS 458-37-7-Calbiochem
1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione, NOD2 Signaling Inhibitor I, Nucleotide-binding Oligomerization Domain 2 Signaling Inhibitor I, Histone Acetyltransferase Inhibitor I, HAT Inhibitor I, p300/CBP Inhibitor I

半岛bd体育手机客户端介绍：

半岛bd体育手机客户端说明

一般描述

A cell permeable antitumor and anti-inflammatory agent that acts as an inhibitor of 5-lipoxygenase (IC₅₀= 8 ?M) and cyclooxygenase (IC₅₀= 52 ?M). Confers significant protection against neurotoxic and genotoxic agents. Also inhibits the induction of nitric oxide synthase in activated macrophages (IC₅₀= 6 ?M). Recently shown to inhibit the EGF receptor intrinsic kinase activity in the human epidermoid carcinoma A431 cells in a dose- and time-dependent manner. Also shown to be a p300/CREB-binding protein-specific inhibitor of histone acetyltransferase, inhibiting the acetylation of histones H3 and H4 with an

IC₅₀of ~25 ?M. Does not affect p300/CREB binding protein-associated factor (PCAF).
A cell-permeable and irreversible antitumor and anti-inflammatory agent that acts as an inhibitor of 5-lipoxygenase (IC₅₀= 8 ?M) and cyclooxygenase (IC₅₀= 52 ?M). Confers significant protection against neurotoxic and genotoxic agents. Also inhibits the induction of nitric oxide synthase in activated macrophages (IC₅₀= 6 ?M). Recently shown to inhibit the EGF receptor intrinsic kinase activity in the human epidermoid carcinoma A431 cells in a dose- and time-dependent manner. Also shown to be a p300/CREB-binding protein-specific inhibitor of histone acetyltransferase, inhibiting the acetylation of histones H3 and H4 with an IC₅₀of ~25 ?M. Does not affect p300/CREB binding protein-associated factor (PCAF).

包装

100 mg in Plastic ampoule

生化/生理作用

Cell permeable: yes
Primary Target
5-lipoxygenase
Product does not compete with ATP.
Reversible: no
Target IC₅₀: 8 ?M, 52 ?M, against 5-lipoxygenase, Cyclooxygenase, respectively; 6 ?M inhibiting the induction of nitric oxide synthase in activated macrophages

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Hung, S., et al. 2008.Mol. Pharmacol.74,274.
Cui, L., et al. 2007.Antimicrob. Agents Chemother.51,488.
Salvioli, S., et al. 2007.eCAM4,181.
Balasubramanyam, K. et al. 2004.J. Biol. Chem.279,51163.
Brouet, I., and Okshima, H. 1995.Biochem. Biophys. Res. Commun.206,533.
Korutla, L., and Kumar, R. 1994.Biochim. Biophys. Acta1224,597.
Flynn, D.L., et al. 1986.Prostagland. Leuk. Med.22,357.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C₂₁H₂₀O₆
分子量	368.38
MDL编号	MFCD00008365
NACRES	NA.77

半岛bd体育手机客户端性质

质量水平	100
测定	≥80% (HPLC)
形式	solid
manufacturer/tradename	Calbiochem^?
储存条件	OK to freeze protect from light
颜色	orange-yellow
溶解性	acetic acid: 10 mg/mL DMSO: 5 mg/mL
运输	ambient
储存温度	10-30℃
InChI	1S/C21H20O6/c1-26-20-11-14(5-9-18(20)24)3-7-16(22)13-17(23)8-4-15-6-10-19(25)21(12-15)27-2/h3-13,22,24-25H,1-2H3/b7-3+,8-4+,16-13-
InChI key	ZIUSSTSXXLLKKK-KOBPDPAPSA-N

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

Curcumin,Curcuma longaL.-CAS 458-37-7-Calbiochem