Cisplatin-CAS 15663-27-1-Calbiochem

半岛bd体育手机客户端 说明

一般描述

A platinum coordination complex with potent anti-neoplastic activity. Induces apoptosis in cancer cells, possibly via caspase-3 activation. Reported to sensitize glioma cells to TNF-α-induced apoptosis.

Note: Athough highly soluble in DMSO, Cisplatin is reported to be rendered inactive due to ligand displacement by the nucleophilic sulfur of DMSO. Sodium chloride solution in water (154 mM NaCl with or without 10 mg/ml mannitol) or PBS (with 140 mM NaCl) is recommended for solubilization prior to culture treatment.
A platinum coordination complex with potent antineoplastic activity.



Note: Athough highly soluble in DMSO, Cisplatin is reported to be rendered inactive due to ligand displacement by the nucleophilic sulfur of DMSO. Sodium chloride solution in water (154 mM NaCl with or without 10 mg/ml mannitol) or PBS (with 140 mM NaCl) is recommended for solubilization prior to culture treatment.

包装

50 mg in Glass bottle

生化/生理作用

Product does not compete with ATP.
Reversible: no
Cell permeable: no
Primary Target
Induces apoptosis in cancer cells

警告

Toxicity: Toxic & Carcinogenic / Teratogenic (G)

重悬

Unstable in solution; reconstitute just prior to use.

其他说明

Hall, M.D., et al. 2014.Cancer Res.In press.
Duan, L., et al. 2001.J. Neurooncol.52,23.
Mese, H., et al. 2000.Cancer Chemother. Pharmacol.46,241.
Von Hoff, D.D., and Rozencweig, M. 1979. inAdv. Pharmacol. Chemother.16,279.
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

线性分子式	Pt(NH3)2Cl2
MDL编号	MFCD00011623
NACRES	NA.77

半岛bd体育手机客户端 性质

质量水平	100
测定	≥98% (HPLC)
形式	solid
manufacturer/tradename	Calbiochem?
储存条件	OK to freeze
颜色	yellow
溶解性	PBS with 140 mM NaCl: 1 mg/mL water with 154 mM NaCl: 1 mg/mL DMSO: 10 mg/mL
运输	ambient
储存温度	2-8℃
InChI	1S/2Cl.2H3N.Pt/h;;2*1H3;
InChI key	JFUARQHXOQHNLK-UHFFFAOYSA-N

安全信息

象形图
警示用语：	Danger
危险声明	H300 - H315 - H317 - H319 - H334 - H335 - H350
预防措施声明	P202 - P261 - P280 - P301 + P310 - P302 + P352 - P305 + P351 + P338
危险分类	Acute Tox. 2 Oral - Carc. 1B - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
靶器官	Respiratory system
储存分类代码	6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable