半岛bd体育手机客户端 说明
一般描述
A cell-permeable, nonsterol, benzenesulfonamide compound that acts as a highly selective and potent liver X receptor agonist (EC50= 20 nM for LXRα). Reported to induce the expression of genes associated with fatty acid biosynthesis. Raises the levels of serum HDL cholesterol and triglycerides in mice and inhibits the development of atherosclerosis in LDL receptor-deficient mice. Also shown to lower plasma glucose levels in diabetic rodents.
A cell-permeable, nonsterol, benzenesulfonamide compound that acts as a highly selective and potent liver X receptor agonist (EC50of 20 nM for LXRα). Reported to induce the expression of genes associated with fatty acid biosynthesis and raise both the levels of serum HDL cholesterol and triglyceride in mice. Also reduces the development of atherosclerosis in LDL receptor-deficient mice and lowers plasma glucose in diabetic rodents.
包装
10 mg in Plastic ampoule
Packaged under inert gas
生化/生理作用
Cell permeable: yes
Product does not compete with ATP.
Reversible: no
Primary Target
Liver X receptor (LXRα)
EC50 = 20 nM for LXRα
警告
Toxicity: Harmful (C)
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
其他说明
Terasaka, N., et al. 2003.FEBS Lett.536,6.
Cao, G., et al. 2002.J. Biol. Chem.278,1131.
Field, F.J., et al. 2002.Biochem. J.368,855.
Fukumoto, H., et al. 2002.J. Biol. Chem.277,48508.
DeBose-Boyd, R.A., et al. 2001.Proc. Natl. Acad. Sci. USA98,1477.
Repa, J.J., et al. 2000.Science289,1524.
Schultz, J.R., et al. 2000.Genes Dev.14,2831.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C17H12F9NO3S |
| 分子量 | 481.33 |
| MDL编号 | MFCD03412028 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | ≥98% (HPLC) |
| 形式 | solid |
| manufacturer/tradename | Calbiochem? |
| 储存条件 | OK to freeze protect from light |
| 颜色 | light beige |
| 溶解性 | DMSO: 50 mg/mL ethanol: 50 mg/mL |
| 运输 | wet ice |
| 储存温度 | ?20℃ |
| InChI | 1S/C17H12F9NO3S/c18-14(19,20)10-27(31(29,30)13-4-2-1-3-5-13)12-8-6-11(7-9-12)15(28,16(21,22)23)17(24,25)26/h1-9,28H,10H2 |
| InChI key | SGIWFELWJPNFDH-UHFFFAOYSA-N |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
