IGF-1R Inhibitor II, PQ401-CAS 196868-63-0-Calbiochem

半岛bd体育手机客户端 说明

一般描述

A cell-permeable phenylquinolinyl-urea compound that inhibits IGF-1R autophosphorylation (IC₅₀= 12 ?M in inhibiting ligand-induced autophosphorylation in MCF-7 cells and <1 ?M in a cell-free kinase assay). Reduces IGF-1R-dependent tumor cell growth bothin vitro(IC₅₀= 8 and 15 ?M for MCF-7 and MCNeuA, respectively) and in micein vivo(80% reduction, 100 mg/kg thrice a week per i.p.). The mechanism of inhibition probably involves indirect blocking of ATP binding.
A cell-permeable phenylquinolinyl-urea compound that inhibits IGF-1R autophosphorylation (IC₅₀= 12 ?M in inhibiting ligand-induced autophosphorylation in MCF-7 cells and <1 ?M in a cell-free kinase assay). Reduces IGF-1R-dependent tumor cell growth bothin vitro(IC₅₀= 8 and 15 ?M for MCF-7 and MCNeuA, respectively) and in micein vivo(80% reduction, 100 mg/kg thrice a week, i.p.). The mechanism of inhibition probably involves indirect blocking of ATP binding.

包装

10 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Product does not compete with ATP.
Reversible: no
Primary Target
IGF-1R
Target IC₅₀: 12 ?M in inhibiting ligand-induced IGF-1R autophosphorylation in MCF-7 cells and <1 ?M in a cell-free kinase assay; 8 and 15 ?M in reducing IGF-1R-dependent tumor cell growth bothin vitrofor MCF-7 and MCNeuA, respectively

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他说明

Gable, K.L., et al. 2006.Mol. Cancer Ther.5,1079.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C18H16ClN3O2
分子量	341.79
MDL编号	MFCD00160558

半岛bd体育手机客户端 性质

质量水平	100
测定	≥98% (HPLC)
形式	solid
manufacturer/tradename	Calbiochem?
储存条件	OK to freeze protect from light
颜色	white
溶解性	DMSO: 10 mg/mL ethanol: 3 mg/mL
运输	ambient
储存温度	2-8℃

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable