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位置: 首页> 品牌> Sigma-Aldrich> Syk Inhibitor IV, BAY 61-3606-CAS 732938-37-8-Calbiochem

Syk Inhibitor IV, BAY 61-3606-CAS 732938-37-8-Calbiochem

品牌
Sigma-Aldrich
CAS
732983-37-8
货号
574714
规格纯度
The Syk Inhibitor IV, BAY 61-3606, also referenced under CAS 732938-37-8, controls the biological activity of Syk. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
价格
2950.71 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
732983-37-8
Syk Inhibitor IV, BAY 61-3606-CAS 732938-37-8-Calbiochem
2-(7-(3,4-Dimethoxyphenyl)-imidazo[1,2-c]pyrimidin-5-ylamino)-nicotinamide, HCl, BAY 61-3606
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

A cell-permeable imidazopyrimidine compound that acts a potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase activity (IC50= 10 nM) with no inhibitory effect against Btk, Fyn, Itk, Lyn, and Src even at concentrations as high as 4.7 ?M. Shown to inhibit Syk-mediated cellular functionsin vitroand exhibit good oral bioavailability andin vivoeffacacy in the treatment of various allgery and asthma conditions in rat models.

包装

2 mg in Glass bottle
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Primary Target
Syk
Product competes with ATP.
Reversible: yes

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Yamamoto, N., et al. 2003.J. Pharm. Exp. Ther.306,1174.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式 C20H18N6O3· xHCl · yH2O
分子量 390.40 (anhydrous free base basis)

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥97% (HPLC)
形式 solid
效能 10 nM IC50
manufacturer/tradename Calbiochem?
储存条件 OK to freeze
desiccated (hygroscopic)
protect from light
颜色 yellow
溶解性 DMSO: 10 mg/mL
water: 20 mg/mL
运输 ambient
储存温度 2-8℃

安全信息

储存分类代码 11 - Combustible Solids
WGK WGK 2
闪点(F) Not applicable
闪点(C) Not applicable

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