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Anti-Mus81 antibody, Mouse monoclonal

品牌
Sigma-Aldrich
货号
M1445
规格纯度
clone MTA30 2G10/3, purified from hybridoma cell culture
价格
4731.57 *本价格含增值税费
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半岛bd体育手机客户端 名称:
Anti-Mus81 antibody, Mouse monoclonal
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Monoclonal Anti-Mus81 (mouse IgG2a isotype) is derived from the hybridoma MTA30 2G10/3 produced by the fusion of mouse myeloma cells (Sp2/0 Ag.14 cells) and splenocytes from BALB/c mice immunized with Mus81 protein. Crossover junction endonuclease Mus81 protein was identified by screening a human cerebellum cDNA library with a probe from the yeast Mus81. The human Mus81 has 551 amino acids with a molecular mass of 59 kDa. The highest sequence similarity between different species is around the VERKX3D motif. This motif is conserved in the endonuclease family (XPF) family of nucleases. The protein has helix-hairpin-helix DNA-binding domains in the N- and C-termini of the protein that are also conserved.

免疫原

Mus81 protein.

应用

Anti-Mus81 antibody, Mouse monoclonal has been used in immunofluorescence, immunoblotting and immunoprecipitation.

生化/生理作用

Crossover junction endonuclease Mus81 is elevated in cells exposed to agents that block DNA replication. Knockout mice that are homozygous Mus81-/-, or their heterozygous cohorts Mus81-/+, are susceptible to spontaneous chromosomal damage and cancer predisposition suggesting that this protein is important for genomic integrity and tumor suppression

外形

0.01M 磷酸缓冲盐溶液,pH 7.4,含 15mM 叠氮化钠。

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号 MFCD08705592
NACRES NA.41

半岛bd体育手机客户端 性质

质量水平 200
生物来源 mouse
偶联物 unconjugated
抗体形式 purified from hybridoma cell culture
antibody product type primary antibodies
克隆 MTA30 2G10/3, monoclonal
形式 buffered aqueous solution
分子量 antigen ~59 kDa
species reactivity human, monkey
technique(s) immunoprecipitation (IP): suitable
western blot: 0.5-1 μg/mL using HEK-293T total cell extract
同位素/亚型 IgG2a
UniProt登记号 Q96NY9
运输 dry ice
储存温度 ?20℃
Gene Information human ... MUS81(80198)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 2
闪点(F) Not applicable
闪点(C) Not applicable

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