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Anti-MRP1 antibody,Mouse monoclonal

品牌
Sigma-Aldrich
货号
M9067
规格纯度
clone QCRL-1, purified from hybridoma cell culture
价格
8419.1 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
Anti-MRP1 antibody,Mouse monoclonal
Anti-Multidrug Resistance Associated Protein 1
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Monoclonal Anti-MRP1 (mouse IgG1 isotype) is derived from the QCRL-1 hybridoma produced by the fusion of mouse myeloma cells (SP2/O) and splenocytes from mice immunized with non-denatured membrane preparations of human H69AR small cell lung cancer cell line, which highly expresses MRP1.
Multidrug resistance associated protein 1 (MRP1) is present in subcellular vesicles and is composed of 1531 amino acids. It has a molecular weight of 190kDa. The gene encoding MRP1 is localized in human chromosome 16p13.11.

特异性

Does not cross-react with the human MDR1 and MDR3, mouse MRP1, and human MRP2, MRP3, MRP4, MRP5, and MRP6 gene products. The antibody may cross-react with canine MRP1.

免疫原

non-denatured membrane preparations of H69AR human small cell lung cancer cell line, which highly expresses MRP1. The epitope resides within amino acids 918-924 of human MRP1.

应用

Monoclonal Anti-MRP1 antibody produced in mouse has been used in:

  • western blotting
  • immunohistochemistry
  • flow cytometry
  • immunoprecipitation
  • immunocytochemistry

包装

200 μL in glass insert

生化/生理作用

Multidrug resistance associated protein 1 (MRP1) functions in the metabolism of many drugs. It is involved in transporting different biomolecules and anticancer drugs like prostaglandins, glutathione, alkaloids and anthracyclines. MRP1 offers resistance to chemotherapy to cells in solid tumors.

外形

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% BSA and 15 mM sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号 MFCD01865488
NACRES NA.41

半岛bd体育手机客户端 性质

质量水平 200
生物来源 mouse
偶联物 unconjugated
抗体形式 purified from hybridoma cell culture
antibody product type primary antibodies
克隆 QCRL-1, monoclonal
形式 buffered aqueous solution
分子量 antigen ~190 kDa
species reactivity human
浓度 ~2 mg/mL
technique(s) flow cytometry: suitable
immunocytochemistry: 10-20 μg/mL using cultured HeLa cells or HepG2 human hepatocellular carcinoma cells
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable
同位素/亚型 IgG1
UniProt登记号 P33527
运输 dry ice
储存温度 ?20℃
Gene Information human ... ABCC1(4363)

Sigma-Aldrich

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