Merbarone

半岛bd体育手机客户端 说明

应用

Merbarone has been used to study its effect on the occurrence of DNA lesions.

包装

25 mg in glass bottle

生化/生理作用

Thiobarbituric acid with aniline joined by an amide linkage forms merbarone. It is known to prolong cell cycle progression by inducing DNA double strand breaks, retarding S phase and arresting G2 phase. This delays cell entry into mitosis. Merbarone possesses cytotoxic and genotoxic action and promotes endoreduplication. Merbarone has mild antitumor action and is also found to nephrotoxic.
Selective topoisomerase II inhibitor. Blocks topo II-mediated DNA cleavage without stabilizing DNA-topo II-cleavable complexes. Induces apoptosis in CEM cells via caspase 3 dependent mechanism.

基本信息

经验(实验)分子式	C11H9N3O3S
分子量	263.27
MDL编号	MFCD00866337
PubChem化学物质编号	24724534

半岛bd体育手机客户端 性质

测定	≥98% (HPLC)
形式	solid
drug control	regulated under CDSA - not available from sigma-aldrich Canada
溶解性	DMSO: >5 mg/mL
储存温度	2-8℃
SMILES string	O=C1NC(=S)NC(=O)C1C(=O)Nc2ccccc2
InChI	1S/C11H9N3O3S/c15-8(12-6-4-2-1-3-5-6)7-9(16)13-11(18)14-10(7)17/h1-5,7H,(H,12,15)(H2,13,14,16,17,18)
InChI key	JARCFMKMOFFIGZ-UHFFFAOYSA-N

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves, type N95 (US)