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Anti-MCH antibody produced in rabbit

品牌
Sigma-Aldrich
货号
M8440
规格纯度
IgG fraction of antiserum, buffered aqueous solution
价格
4692 *本价格含增值税费
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数量
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半岛bd体育手机客户端 名称:
Anti-MCH antibody produced in rabbit
MCH Antibody-Anti-MCH antibody produced in rabbit
Mch Antibody
Anti-Melanin-Concentrating Hormone
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Melanin-concentrating hormone (MCH) is a circulating 19-amino acid residue cyclic neuropeptide present in hypothalamus. In mammals, MCH is a, encoded by the precursor pro-melanin concentrating hormone (PMCH). It was first discovered in fish and subsequently in mammalian (rat). MCH perikarya is confined largely to the lateral hypothalamus area (LHA) and the adjacent zon incerta with extensive neuronal projections throughout the brain. MCH is detected in basal ganglia, neocortex, cerebellum, thymus, brown adipose tissue, duodenum, and testis. The structure of MCH is highly conserved among species.

免疫原

synthetic peptide corresponding to human melanin-concentrating hormone conjugated to KLH. The MCH sequence is identical in many species including rat, mouse, and pig.

应用

Anti-MCH antibody produced in rabbit has been used in radioimmunoassay and immunohistochemistry.
Anti-MCH antibody may be used at a working dilution of 1:30000 for RIA. For immunohistochemistry of mouse hypothalamus sections, a working antibody dilution of 1:200 may be used. The antibody has been used for immunoblotting in cytoplasmic extracts of T cells at a concentration of 5.7 μg/ml. The antibody is suitable for protein microarray.

生化/生理作用

MCH mRNA is overexpressed and up-regulated during fasting in the hypothalamus of ob/ob mice as well as rats. Injection of MCH into the lateral ventricles in rats promote increased food consumption. In addition, knockout mice lacking MCH gene are lean and hypophagic and show an increase in metabolic rate. In contrast, overexpression of MCH in transgenic mice leads to obesity and insulin resistance.

外形

Solution in phosphate buffered saline containing 15 mM sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号 MFCD03791841
NACRES NA.46

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 200
偶联物 unconjugated
抗体形式 IgG fraction of antiserum
antibody product type primary antibodies
克隆 polyclonal
形式 buffered aqueous solution
species reactivity human
technique(s) indirect ELISA: 1:2,500
microarray: suitable
UniProt登记号 P20382
运输 dry ice
储存温度 ?20℃
Gene Information human ... PMCH(5367)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK nwg
闪点(F) Not applicable
闪点(C) Not applicable

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