SCF-Skp2 Protein Complex, Active, 10 μg

半岛bd体育手机客户端 说明

一般描述

The SCF (Skp1-Cul1-F-box protein) complexes represent the largest family of ubiquitin-protein ligases and mediate the ubiquitination of a broad spectrum of regulatory and signalling proteins in diverse cellular pathways. The SCF consists of three invariant components, Skp1, Cul1 and Rbx1 and an interchangeable subunit, an F-box protein which is responsible for recruiting specific substrates to be ubiquitinated by the SCF. SCF^Skp2mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. It specifically recognizes phosphorylated p27 and is involved in regulation of G1/S transition. Complex formation of SCF^Skp2with Cks1 is required for the degradation of p27. An increased level of Skp2 and reduced level of p27 is linked to poor prognosis in a number of cancers

应用

Ubiquitination Cascade Comoponent: E3

外形

Purified using immobilized metal affinity chromatography.

其他说明

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

法律信息

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss	32160405
NACRES	NA.41

半岛bd体育手机客户端 性质

质量水平	100
生物来源	human
manufacturer/tradename	Upstate?
technique(s)	activity assay: suitable
NCBI登记号	NM_001826 NM_003592 NM_005983 NM_014248 NM_170679
Gene Information	human ... Cks1(1163), Cul1(8454), Rbx1(9978), Skp1(6500), Skp2(6502)