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位置: 首页> 品牌> Sigma-Aldrich> FGFR1 (V561M) Protein, active, 10 μg

FGFR1 (V561M) Protein, active, 10 μg

品牌
Sigma-Aldrich
货号
14-734-M
规格纯度
Active, N-terminal GST-tagged, recombinant, human FGFR1 amino acids 456 -765 containing the V561 mutation. For use in Enzyme Assays.
价格
7211.57 *本价格含增值税费
促销
服务
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数量
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半岛bd体育手机客户端 名称:
FGFR1 (V561M) Protein, active, 10 μg
Basic Fibroblast Growth Factor Receptor 1, c-fgr, CD331
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

N-terminal GST-tagged, recombinant, human FGFR1 amino acids 456 - 765 containing the V561 mutation. The coordinates for recombinant human FGFR1 were described in Homann et al. (2001). Blencke et al. (2004) suggested mutations to a conserved threonine residue at the ATP binding site would result in inhibitor resistance. The amino acid valine 561 was mutated to a methionine in FGFR1 which corresponded to previously reported mutations found in Abl (T315) and EGFR (T766) which had been shown to confer resistance to selective inhibitors. Assay data for FGFR1 V561M had shown that this mutation had conferred resistance to PP58 (pyrido [2,3-d] pyrimidine tyrosine kinase inhibitor) compared to that of the wild type.
Product Source: Recombinant human FGFR1 expressed by baculovirus in Sf21 cells.

应用

Research Category
Metabolism
Research Sub Category
Obesity

Metabolic Disorders

生化/生理作用

Protein Target: FGFR1
Target Sub-Family: TK

质量

Routinely evaluated by phosphorylation of 500μM GGEEEEYFELVKKKK

外形

Presented as a frozen solution in 50mM Tris/HCl pH 7.5, 300mM NaCl, 0.1mM EGTA, 0.03% Brij 35, 270mM sucrose, 1mM benzamidine, 0.2mM PMSF, 0.1% 2-mercaptoethanol.
Glutathione-agarose

储存及稳定性

Stable for 6 months at -70°C from date of shipment. Upon first use, rapidly thaw the vial under cold water and immediately place on ice. Aliquot unused material into pre-chilled microcentrifuge tubes and immediately snap-freeze the vials in liquid nitrogen prior to re-storage at -70°C.

其他说明

Please see lot specific Certificarte of Analysis.
Concentration: Please see lot specific Certificarte of Analysis.
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

法律信息

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss 32160405
NACRES NA.32

半岛bd体育手机客户端 性质

质量水平 100
生物来源 human
分子量 Mw62.3 kDa
manufacturer/tradename Upstate?
technique(s) activity assay: suitable
NCBI登记号 NM_015850.3
NM_023105.2
NM_023106.2
NM_023107.2
NM_023108.2
NM_023110.2
NM_023111.2
UniProt登记号 P11362
Gene Information human ... FGFR1(2260)

安全信息

象形图 GHS07
警示用语: Warning
危险声明 H317
预防措施声明 P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
危险分类 Skin Sens. 1
储存分类代码 10 - Combustible liquids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

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