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c-Cbl Protein, active, 10 μg

品牌
Sigma-Aldrich
货号
23-041-M
规格纯度
Active, full length, recombinant human c-Cbl. N-terminal GST-tagged. For use in Enzyme Assays. Functions as an E3 ligase in ubiquitination assays.
价格
8243.79 *本价格含增值税费
促销
服务
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数量
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半岛bd体育手机客户端 名称:
c-Cbl Protein, active, 10 μg
E3 ubiquitin-protein ligase CBL, Casitas B-lineage lymphoma proto-oncogene, RING finger protein 55, Signal transduction protein CBL, CBL2, RNF55
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Intracellular signals mediated by receptor tyrosine kinases play a pivotal role in morphogenesis, cell fate determination and pathogenesis. c-Cbl is a ubiquitin ligase (E3) that facilitates the regulation of these pathways, attenuating signalling through ubiquitination and subsequent protein degradation. c-Cbl contains several functional domains, including a tyrosine kinase-binding domain that associates with a number of protein tyrosine kinases in a phosphorylation-dependent manner, a catalytic RING-finger domain that interacts with E2s and is essential for E3 activity and a C-terminal proline rich domain which mediates interactions with SH3 containing proteins. Mutations in the gene for c-Cbl have been implicated in a number of human cancers, particularly acute myeloid leukaemia.
N-terminal cMyc and GST-tagged, recombinant human IKKγ full length, expressed by baculovirus in Sf21 insect cells.

应用

Ubiquitination Cascade Comoponent: E3

外形

Purified using glutathione sepharose.

其他说明

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

法律信息

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss 32160405
NACRES NA.41

半岛bd体育手机客户端 性质

质量水平 300
100
生物来源 human
manufacturer/tradename Upstate?
technique(s) activity assay: suitable
NCBI登记号 NM_005188

安全信息

象形图 GHS07
警示用语: Warning
危险声明 H317
预防措施声明 P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
危险分类 Skin Sens. 1
储存分类代码 10 - Combustible liquids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

Sigma-Aldrich

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