您好,欢迎来到半岛电竞官方网址 ! [ 登录] [ 免费注册]
半岛电竞官方网址
位置: 首页> 品牌> Sigma-Aldrich> TGFBR-1 Protein, active, 10 μg

TGFBR-1 Protein, active, 10 μg

品牌
Sigma-Aldrich
货号
14-912-M
规格纯度
Active, N-terminal GST-tagged, recombinant, human TGFBR1 amino acids 200-end containing a T204D mutation, expressed by baculovirus in Sf21 insect cells. Purified using glutathione agarose. For use in Kinase Assays.
价格
5605.57 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
- +
半岛bd体育手机客户端 名称:
TGFBR-1 Protein, active, 10 μg
TGF-beta receptor type-1, TGFR-1, Transforming growth factor-beta receptor type I, TGF-beta receptor type I, TbetaR-I, TGF-beta type I receptor, Serine/threonine-protein kinase receptor R4, SKR4, Activin receptor-like kinase 5, ALK-5
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Transforming growth factor, beta receptor type I (TGF-beta receptor I) forms a heteromeric complex with TGF-beta receptor type II when bound to TGF-beta. This complex transduces the TGF-beta signal from the cell surface to the cytoplasm. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. TGF-beta receptor I is found in all tissues, but is most abundant in placenta and least abundant in brain and heart tissue. TGF-beta receptor I is phosphorylated at basal levels in the absence of ligand binding and is multiply phosphorylated, mainly in the GS region. Defects in TGF-beta receptor I are the cause of Loeys-Dietz syndrome type 1A (LDS1A), also known as Furlong syndrome or Loeys-Dietz aortic aneurysm syndrome (LDAS).
Product Source: Expressed by baculovirus in Sf21 insect cells.
N-terminal GST-tagged, recombinant, human TGFBR1 amino acids 200–end containing a T204D mutation, expressed by baculovirus in Sf21 insect cells. Purified using glutathione agarose.

应用

Research Category
Inflammation & Immunology

生化/生理作用

Target Sub-Family: TKL
Protein Target: TGFBR1

包装

Also available in 250 ?g size --call for pricing and availability and reference catalog number 14-912M when ordering the 250 ?g size.

质量

Routinely evaluated by phosphorylation of casein.

外形

Glutathione agarose affinity chromatography
50mM Tris-HCl pH7.5, 300mM NaCl, 0.1mM EGTA, 0.03% Brij-35, 270mM sucrose, 1mM benzamidine, 0.2mM PMSF, 0.1% 2-mercaptoethanol. Frozen solution.

储存及稳定性

Store -70°C. For maximum recovery of product, centrifuge original vial prior to removing the cap.
Rapidly thaw the vial under cold water and immediately place on ice. Aliquot unused material into pre-chilled microcentrifuge tubes and immediately snap-freeze the vials in liquid nitrogen prior to re-storage at -70°C.

其他说明

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

法律信息

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss 32160405
NACRES NA.32

半岛bd体育手机客户端 性质

质量水平 100
生物来源 human
分子量 Mw62 kDa
manufacturer/tradename Upstate?
technique(s) activity assay: suitable (kinase)
NCBI登记号 NM_004612
UniProt登记号 P36897
Q64729 (mouse)
Gene Information human ... TGFBR1(7046)

Sigma-Aldrich

推荐半岛bd体育手机客户端
Baidu
map