半岛bd体育手机客户端 说明

包装

10 mg in glass bottle
50 mg in poly bottle

生化/生理作用

Luotonin A is a cytotoxic alkaloid reported to inhibit topoisomerase I. Luotonin A was originally isolated from the Chinese medicinal plantPaganum nigellastrum. As an antitumor agent, Luotonin A demonstrates cytotoxic activity against the mouse leukemic cell line P-388 at low concentrations (IC₅₀1.8μg/mL). Luotonin A stabilizes the cleavable human topoisomerase I-DNA binary complex resulting in cytotoxicity to cells (IC₅₀5.07-12.6 μM).Luotonin forms non-covalent complexes with ds-DNA in the minor groove. It may serve as a prototype for analytical probes of DNA hybridization.

重悬

Solubility is tested at 4 mg/mL in 1:1 solution of choloform and methanol. Solubility of luotonins in DMSO has been reported.

基本信息

线性分子式	C18H11N3O
NACRES	NA.77

半岛bd体育手机客户端 性质

质量水平	200
生物来源	synthetic (organic)
测定	≥98% (HPLC)
形式	solid
溶解性	chloroform: methanol (1:1): 4 mg/mL, clear to slightly hazy, colorless to yellow
运输	wet ice
储存温度	?20℃
Gene Information	human ... TOP1(7150)

安全信息

象形图
警示用语：	Danger
危险声明	H301
预防措施声明	P301 + P310
危险分类	Acute Tox. 3 Oral
储存分类代码	6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGK	WGK 2
闪点(F)	Not applicable
闪点(C)	Not applicable