Tyrphostin AG 879

半岛bd体育手机客户端 说明

应用

Tyrphostin AG 879 (AG879) has been used for studying its effect on ErbB2 receptor phosphorylation in A431 cells. This study reported that AG879 at 10 muM can cause 15% inhibition of receptor phosphorylation¹. AG879 has also been used as a neurotrophic tyrosine kinase receptor inhibitor to study the disruption of Sertoli cell aggregation².

包装

5 mg in glass bottle

生化/生理作用

Tyrphostin AG 879 is known to block RAF-1 and Her-2 expression and exhibit anticancer functions in breast cancer cells³. Furthermore, AG879 is known to block ETK1-PAK1 interactions and the growth of RAS-induced sarcomas in nude mice⁴.
Inhibits the tyrosine kinase activity of the nerve growth factor receptor (TrkA; pp140trk) and heregulin receptor erbB-2 (HER-2).

特点和优势

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制备说明

Tyrphostin AG 879 is soluble in DMSO at 26/ml and is insoluble in water.

基本信息

经验(实验)分子式	C18H24N2OS
分子量	316.46
MDL编号	MFCD00236450
PubChem化学物质编号	24278728
NACRES	NA.77

半岛bd体育手机客户端 性质

质量水平	100
测定	99% (HPLC)
溶解性	DMSO: soluble (at 26 mg/ml) H2O: insoluble
SMILES string	CC(C)(C)c1cc(\C=C(/C#N)C(N)=S)cc(c1O)C(C)(C)C
InChI	1S/C18H24N2OS/c1-17(2,3)13-8-11(7-12(10-19)16(20)22)9-14(15(13)21)18(4,5)6/h7-9,21H,1-6H3,(H2,20,22)/b12-7+
InChI key	XRZYELWZLNAXGE-KPKJPENVSA-N
Gene Information	human ... ERBB2(2064), NTRK1(4914)

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves, type N95 (US)