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位置: 首页> 品牌> Sigma-Aldrich> Monoclonal Anti-Junctional Sarcoplasmic Reticulum Protein antibody produced in mouse

Monoclonal Anti-Junctional Sarcoplasmic Reticulum Protein antibody produced in mouse

品牌
Sigma-Aldrich
货号
J3253
规格纯度
clone VF1C, diluted ascites fluid
价格
4330.86 *本价格含增值税费
促销
服务
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数量
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半岛bd体育手机客户端 名称:
Monoclonal Anti-Junctional Sarcoplasmic Reticulum Protein antibody produced in mouse
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

The gene Jsrp1 (junctional sarcoplasmic reticulum protein 1), also referred to as JP45, encodes an integral protein that contains a predicted cytoplasmic domain, an intralumenal domain that is rich in positively charged amino acids, preceded by a single transmembrane segment. The mRNA has been detected in 17-day-old mouse embryos, with increased expression during the second month of postnatal development. Its expression decreases 3-fold during aging. The protein is localized to the junctional sarcoplasmic reticulum.

免疫原

rabbit skeletal muscle triads.

生化/生理作用

The gene Jsrp1 (junctional sarcoplasmic reticulum protein 1) encodes an integral protein component of the junctional face membrane of the skeletal muscle sarcoplasmic reticulum. It is found to associate with Cav1.1 (voltage-dependent Ca2+channel) and calsequestrin, a luminal Ca2+-binding protein. The complex formed by Jsrp1 and Cav1.1 is found to be decreased with age and has been linked to decayed muscle strength and physical disability in the elderly. Knock-out of this gene in young mice results in decreased expression of Cav1.1 and diminished muscle strength.

外形

Solution in phosphate buffered saline containing 0.05% sodium azide.

基本信息

MDL编号 MFCD02263551
NACRES NA.41

半岛bd体育手机客户端 性质

质量水平 200
生物来源 mouse
偶联物 unconjugated
抗体形式 diluted ascites fluid
antibody product type primary antibodies
克隆 VF1C, monoclonal
分子量 antigen 90 kDa
species reactivity canine, mouse, rat, guinea pig, rabbit
technique(s) indirect immunofluorescence: suitable
western blot: suitable
UniProt登记号 Q3MI48
运输 dry ice
储存温度 ?20℃
Gene Information mouse ... Jsrp1(71912)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK nwg
闪点(F) Not applicable
闪点(C) Not applicable
个人防护装备 Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Sigma-Aldrich

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