半岛bd体育手机客户端 说明
一般描述
Cell permeable. Approximately five times more potent as an inhibitor of endothelial nitric oxide synthase (IC50= 500 nM) than other arginine analogs, such as L-NAME (Cat. No. 483125) and L-NMMA (Cat. No. 475886). Inhibits acetylcholine induced relaxation of rat aorta rings (IC50= 2 ?M) and causes a dose-dependent increase in mean arterial blood pressure in the rat (EC50= 19.5 mg/kg).
A cell-permeable, more potent inhibitor of endothelial nitric oxide synthase (eNOS; IC50= 500 nM) compared to other arginine analogs such as L-NAME (Cat. No. 483125) and L-NMMA (Cat. No. 475886). Inhibits acetylcholine-induced relaxation of rat aorta rings (IC50= 2 ?M) and causes a dose-dependent increase in mean arterial blood pressure in the rat (EC50= 19.5 mg/kg).
包装
20 mg in Plastic ampoule
生化/生理作用
Cell permeable: yes
Primary Target
eNOS
Target IC50: 500 nM against endothelial nitric oxide synthase (eNOS); 2 ?M against acetylcholine-induced relaxation of rat aorta rings; EC50 = 19.5 mg/kg for a dose-dependent increase in mean arterial blood pressure in the rat
Product does not compete with ATP.
Reversible: no
警告
Toxicity: Irritant (B)
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
其他说明
Moore, W.M., et al. 1994.J. Med. Chem.37,3886.
Rees, D.D., et al. 1990.Br. J. Pharmacol.101,746.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C7H15N3O2· 2HCl |
| 分子量 | 246.13 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | ≥98% (TLC) |
| 形式 | solid |
| manufacturer/tradename | Calbiochem? |
| 储存条件 | OK to freeze desiccated (hygroscopic) |
| 颜色 | white |
| 溶解性 | water: 1 mg/mL |
| 运输 | ambient |
| 储存温度 | ?20℃ |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
