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位置: 首页> 品牌> Sigma-Aldrich> Anti-phospho-Integrin β3 (pTyr773) antibody produced in rabbit

Anti-phospho-Integrin β3 (pTyr773) antibody produced in rabbit

品牌
Sigma-Aldrich
货号
I7408
规格纯度
affinity isolated antibody, buffered aqueous solution
价格
4731.57 *本价格含增值税费
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数量
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半岛bd体育手机客户端 名称:
Anti-phospho-Integrin β3 (pTyr 773) antibody produced in rabbit
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

The gene ITGB3 (integrin subunit β 3) encodes the β subunit of integrins, which are transmembrane α/β heterodimers. There are 18 α subunits and 8 β subunits identified in mammals that associate with each other to form 24 different heterodimers. Based on the type of β3 subunit, the heterodimers can be grouped into subfamilies.

免疫原

synthetic phosphopeptide derived from the region of human integrin β3 receptor that contains tyrosine 773. The sequence is conserved in human, mouse, and rat.

生化/生理作用

Integrins function in various cellular processes, such as tissue migration during embryogenesis, cellular adhesion, cancer metastases, and lymphocyte helper and killer cell functions. The β3 subunit is expressed along with αv and αIIb subunits in platelets to form the subfamilies αvβ3 and αIIbβ3. The receptor αvβ3 facilitates platelet adhesion to osteopontin and vitronectinin vitro. But, it is yet to be determined if it functions in platelet adhesionin vivo. The αvβ3 receptor functions as a receptor for fibrinogen, vWF, fibronectin, and vitronectin and participates in platelet aggregation. Any defects in the number or function of this receptor may result in the inhibition of platelet aggregation, leading to the bleeding disorder Glanzmann thrombasthenia.

外形

Solution in Dulbecco′s PBS, containing 1 mg/mL BSA, 50% Glycerol.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号 MFCD06798492
NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 200
偶联物 unconjugated
抗体形式 affinity isolated antibody
antibody product type primary antibodies
克隆 polyclonal
形式 buffered aqueous solution
分子量 antigen 130 kDa
species reactivity human, mouse, rat
technique(s) western blot: 0.1-1.0 μg/mL using K562 cells
UniProt登记号 P05106
运输 dry ice
储存温度 ?70℃
Gene Information human ... ITGB3(3690)
mouse ... Itgb3(16416)
rat ... Itgb3(29302)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

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