Interferon-γ-Inducible Protein-10 human

半岛bd体育手机客户端 说明

一般描述

The gene for C-X-C motif chemokine ligand 10 (CXCL10), also known as interferon-γ-inducible protein-10 (IP-10), is mapped to human chromosome 4q21.1. IP-10 is secreted by monocytes, neutrophils, endothelial cells, keratinocytes, fibroblasts, mesenchymal cells, dendritic cells, astrocytes and hepatocytes. It is a polypeptide of 78 amino acids. Human IP-10 shows 67% amino acid homology to mouse CRG-2.

生化/生理作用

IP-10 (interferon-γ-inducible protein-10) protein is a proinflammatory chemokine which controls immune responses. It interacts with chemokine receptor 3 (CXCR3) and activates leukocytes including T cells, eosinophils, monocytes and natural killer cells. Mutations in IP-10 are associated with rheumatoid arthritis. In humans with chronic hepatitis C virus (HCV) infection or HCV/human immunodeficiency virus (HIV) co-infection, IP-10 is linked with obesity and insulin resistance.
IP-10, a chemoattractant for activated T lymphocytes, is a potent inhibitor of angiogenesis and displays thymus-dependent anti-tumor effects.

外形

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose containing 50 μg bovine serum albumin per 1 μg of cytokine.

分析说明

The biological activity is measured by its ability to chemoattract mouse BaF/3 cells transfected with hCXCR3.

基本信息

MDL编号	MFCD00241912
NACRES	NA.32

半岛bd体育手机客户端 性质

质量水平	100
生物来源	human
重组	expressed inE. coli
测定	≥97% (SDS-PAGE)
形式	lyophilized powder
效能	0.015-0.075 μg/mL ED50(chemoattract mouse BaF3 cells transfected with hCXCR3) 0.03-0.18 μg/mL ED50(chemoattract T-Lymphocytes)
分子量	8.7 kDa
包装	pkg of 10 μg
杂质	endotoxin, tested
UniProt登记号	P01579
储存温度	?20℃
Gene Information	human ... CXCL10(3627)

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 1
闪点(F)	Not applicable
闪点(C)	Not applicable