Insulin-like Growth Factor-I Receptor human

半岛bd体育手机客户端 说明

一般描述

IGF1R (insulin-like growth factor I) is a receptor tyrosine kinase. The gene is mapped to human chromosome 15q26. It is expressed in various solid tumors as well as hematologic malignancies.

应用

Insulin-like growth factor-I receptor human has been used to study the binding constants of estradiol to insulin, insulin receptors and insulin-like peptides.

生化/生理作用

IGF-I receptor, a tyrosine kinase receptor with signal transduction pathways, is comprised of two α and two β subunits. IGF-I receptor binds IGF-I with high affinity, IGF-II with lower affinity, and insulin with weak affinity.

外形

Lyophilized from a 0.2 μm solution in phosphate buffered saline.

分析说明

The biological activity is measured by its ability to bind human IGF-I in a functional ELISA assay.
As a result of glycosylation in SDS-PAGE under reducing conditions, the recombinant α subunit migrates as a doublet of ~120 kDa and 150 kDa and the β subunit migrates as doublet of ~46 kDa and 50 kDa.

基本信息

MDL编号	MFCD01323726
NACRES	NA.32

半岛bd体育手机客户端 性质

质量水平	200
生物来源	human
重组	expressed in NSO cells
测定	≥95% (SDS-PAGE)
形式	lyophilized powder
分子量	α-chain ~120 & 150 kDa β subunit ~46 & 50 kDa
包装	pkg of 50 μg
杂质	endotoxin, tested
UniProt登记号	P08069
储存温度	?20℃
Gene Information	human ... IGF1R(3480)

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves, type N95 (US)