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Monoclonal Anti-Intracellular Adhesion Molecule 3 antibody produced in mouse

品牌
Sigma-Aldrich
货号
I9031
规格纯度
~1 mg/mL, clone 186-2G9, purified immunoglobulin, buffered aqueous solution
价格
4731.57 *本价格含增值税费
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半岛bd体育手机客户端 名称:
Monoclonal Anti-Intracellular Adhesion Molecule 3 antibody produced in mouse
Anti-ICAM-3
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

The gene ICAM3 (intercellular adhesion molecule 3) encodes type I membrane glycoprotein that belongs to the immunoglobulin (ig) superfamily. The encoded protein is extensively glycosylated and contains five Ig-like domains that share high homology with corresponding domains in ICAM-1 and ICAM-2. ICAM3 is found to be expressed on all leukocytes, including the resting leukocytes. The gene is mapped to human chromosome 19p13.2.

免疫原

stimulated human leukocytes.

生化/生理作用

The protein intercellular adhesion molecule 3 (ICAM-3) functions as a receptor for LFA-1 (leukocyte function-associated antigen-1) and mediates adhesive interactions of leukocyte cell surface adhesion molecules in inflammatory and immune response. LFA-1 participates in several processes, such as T cell-mediated killing, T helper and B lymphocyte responses, natural killing, Ab-dependent cellular cytotoxicity by monocytes and granulocytes, and adherence of leukocytes to endothelial cells, fibroblasts, and epithelial cells. ICAM-3 mediates the adhesion of resting T lymphocytes to LFA-1 and participates in the initiation of immune responses. It may also function in lymphocyte activation, as well as in adhesion.

外形

Solution in phosphate buffered saline pH 7.4, containing 0.08% sodium azide.

基本信息

MDL编号 MFCD01094485
NACRES NA.41

半岛bd体育手机客户端 性质

质量水平 200
生物来源 mouse
偶联物 unconjugated
抗体形式 purified immunoglobulin
antibody product type primary antibodies
克隆 186-2G9, monoclonal
形式 buffered aqueous solution
分子量 antigen 120 kDa
species reactivity human
浓度 ~1 mg/mL
technique(s) direct immunofluorescence: 2 μg using 1 mg protein lysate
flow cytometry: 2 μg using 1 mg protein lysate
immunohistochemistry: 2-4 μg/mL using human tonsil tissue sections
immunoprecipitation (IP): 2 μg using 1 mg protein lysate
western blot: 1-5 μg/mL
UniProt登记号 P32942
运输 wet ice
储存温度 ?20℃
Gene Information human ... ICAM3(3385)

安全信息

储存分类代码 12 - Non Combustible Liquids
闪点(F) Not applicable
闪点(C) Not applicable

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