Insulin-Like Growth Factor Binding Protein-2 from mouse

半岛bd体育手机客户端 说明

一般描述

IGFBP2 (insulin-like growth factor binding protein 2) belongs to the IGFBP family of proteins. The protein has two HBD (heparin-binding domain-1) domains. It is a secreted protein.

生化/生理作用

IGFBP2 (insulin-like growth factor binding protein 2) works along with IGF-I (insulin like growth factor I) and regulates cellular proliferation and differentiation. It mainly binds to IGFs and restricts their association to other receptors.
During development, insulin-like growth factor binding protein-2 is expressed in a number of tissues with the highest expression level found in the central nervous system. IGFBP-2 exhibits a 2-10 fold higher affinity for IGF II than for IGF I. Mouse and human IGFBP-2 share approximately 82% homology.

外形

Lyophilized from a 0.2 μm filtered solution of 35% acetonitrile and 0.1% TFA.

分析说明

The biological activity is measured by its ability to inhibit recombinant human lGF-II on MCF-7 cells.

基本信息

MDL编号	MFCD02099094
NACRES	NA.32

半岛bd体育手机客户端 性质

质量水平	200
生物来源	mouse
重组	expressed in NSO cells
测定	≥95% (SDS-PAGE)
形式	lyophilized powder
效能	0.125-0.5 mg per mL ED50
分子量	~35 kDa by SDS-PAGE (reducing) calculated mol wt 29.4 kDa
包装	pkg of 25 μg
technique(s)	cell culture | mammalian: suitable
杂质	endotoxin, tested
UniProt登记号	D3YU40
储存温度	?20℃
Gene Information	mouse ... Igfbp2(16008)

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves, type N95 (US)