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位置: 首页> 品牌> Sigma-Aldrich> 抗-胰岛素样生长因子-I 山羊抗

Anti-Insulin-Like Growth Factor-I antibody produced in goat

抗-胰岛素样生长因子-I 山羊抗

品牌
Sigma-Aldrich
货号
I8773
规格纯度
affinity isolated antibody
价格
5009.98 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
Anti-Insulin-Like Growth Factor-I antibody produced in goat
Anti-IGF-I
抗-胰岛素样生长因子-I 山羊抗
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Insulin-like growth factors -1 and -2 are important regulators of signalling that mediates growth and metabolism in cells. Insulin-like growth factor -1 shares structural homology with proinsulin and is mainly produced by liver. IGF-1 acts via specific receptor, IGF-1R, a heterodimeric tyrosine kinase receptor that signals to various second messenger pathways such as MAPK, Raf/Ras and PI3K cascades. The effect of IGF-1 is by endocrine, paracrine and autocrine signalling. The effects of IGF-1 signalling are important at many developmental levels from cells to organ to organism, growth, differentiation, anti-apoptosis, proliferation and transformation. Irregular IGF-1 signaling has been implicated in many cancers including melanoma, breast, lung, colon and prostate
Anti-IGF-I recognizes human insulin-like growth factor I. The antibody does not react with human IGF-II.

特异性

The antibody neutralizes the biological activity of recombinant human IGF-I.

免疫原

recombinant human IGF-I expressed inEscherichia coli

应用

Anti- IGF-1 antibody may be used for neutralization reactions, the ND50 of the antibody is 3-12 μg/ml. For immunoblotting a working antibody concentration of 0.1-0.2 μg/ml.

外形

Lyophilized from a 0.2 μm filtered solution of phosphate buffered saline, pH 7.4, with 5% trehalose.

制备说明

Affinity isolated by IGF-I affinity chromatography.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号 MFCD00162566

半岛bd体育手机客户端 性质

质量水平 100
生物来源 goat
偶联物 unconjugated
抗体形式 affinity isolated antibody
antibody product type primary antibodies
克隆 polyclonal
形式 lyophilized powder
species reactivity human
technique(s) neutralization: 3-12 μg/mL
western blot: 0.1-0.2 μg/mL
UniProt登记号 P05019
储存温度 ?20℃
Gene Information human ... IGF1(3479)

安全信息

储存分类代码 11 - Combustible Solids
WGK WGK 2
闪点(F) Not applicable
闪点(C) Not applicable
个人防护装备 Eyeshields, Gloves, type N95 (US)

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