半岛bd体育手机客户端 说明
一般描述
Icilin is a synthetic cooling agent and modulates human transient receptor potential cation channel (TRPA1). Icilin inhibits transient receptor potential cation channel subfamily M member 8 (TRPM8) and modulates calcium release. Icilin also suppresses transient receptor potential vanilloid subtype 3 (TRPV3).
应用
Icilin has been used as cooling agent in anterior ventromedial preoptic area (VMPO) neurons.
包装
10, 50 mg in glass bottle
生化/生理作用
Icilin is a potent agonist at the CMR1 cold- and menthol-sensitive receptor.
基本信息
经验(实验)分子式 | C16H13N3O4 |
分子量 | 311.29 |
MDL编号 | MFCD01689072 |
PubChem化学物质编号 | 24277906 |
NACRES | NA.77 |
半岛bd体育手机客户端 性质
质量水平 | 100 |
测定 | ≥97% (HPLC) |
形式 | solid |
颜色 | yellow |
溶解性 | DMSO: 15 mg/mL |
SMILES string | Oc1ccccc1N2CC=C(NC2=O)c3cccc(c3)[N+]([O-])=O |
InChI | 1S/C16H13N3O4/c20-15-7-2-1-6-14(15)18-9-8-13(17-16(18)21)11-4-3-5-12(10-11)19(22)23/h1-8,10,20H,9H2,(H,17,21) |
InChI key | RCEFMOGVOYEGJN-UHFFFAOYSA-N |
安全信息
储存分类代码 | 13 - Non Combustible Solids |
WGK | WGK 3 |
闪点(F) | Not applicable |
闪点(C) | Not applicable |
个人防护装备 | dust mask type N95 (US), Eyeshields, Gloves |
Sigma-Aldrich