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位置: 首页> 品牌> Sigma-Aldrich> Anti-phospho-IRF-3 (Ser396) Antibody

Anti-phospho-IRF-3 (Ser396) Antibody

品牌
Sigma-Aldrich
货号
07-582-I
规格纯度
from rabbit, purified by affinity chromatography
价格
5352.52 *本价格含增值税费
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半岛bd体育手机客户端 名称:
Anti-phospho-IRF-3 (Ser396) Antibody
Interferon regulatory factor 3, IRF-3
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Interferon regulatory factors (IRFs) comprise a family of transcription factors that function with the Jak/Stat pathway to regulate interferon (IFN) and IFN-inducible gene expression in response to viral infection. IRF-3 can inhibit cell growth and plays a critical role in controlling the expression of genes in the innate immune response. In unstimulated cells, IRF-3 is present in the cytoplasm. Viral infection results in phosphorylation of IRF-3 and leads to its translocation to the nucleus where it activates promoters containing IRF-3-binding sites. Phosphorylation of IRF-3 occurs at a cluster of C-terminal serine and threonine residues (between 385 and 405) leading to its association with the p300/CBP coactivator protein that promotes DNA binding and transcriptional activity.

特异性

This antibody recognizes IRF-3 phosphorylated at Ser396.

免疫原

Epitope: SNS → ANA: Mutation of this residue results in loss of viral-induced phosphorylation of IRF-3.
KLH-conjugated linear peptide corresponding to human IRF-3 phosphorylated at Ser396.

应用

Research Sub Category
Transcription Factors
Research Category
Epigenetics & Nuclear Function
Use Anti-phospho-IRF-3 (Ser396) Antibody (Rabbit Polyclonal Antibody) validated in WB to detect phospho-IRF-3 (Ser396) also known as Interferon regulatory factor 3.

质量

Evaluated by Western Blot in untreated and sendai virus treated A549 cell lysates.

Western Blot Analysis: A 1:1,000 dilution of this antibody detected phospho-IRF-3 (Ser396) in 10 ?g of sendai virus treated A549 cell lysate.

目标描述

~50 kDa observed. Uncharacterized bands may appear at ~40 kDa and ~80 kDa in some lysates.

联系

Replaces: 07-582

外形

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Affinity purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

分析说明

Control
Untreated and sendai virus treated A549 cell lysates

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss 32160702
NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 100
抗体形式 affinity isolated antibody
antibody product type primary antibodies
克隆 polyclonal
纯化方式 affinity chromatography
species reactivity human
species reactivity (predicted by homology) porcine (based on 100% sequence homology), rhesus macaque (based on 100% sequence homology)
technique(s) western blot: suitable
NCBI登记号 NP_001562
UniProt登记号 Q14653
运输 wet ice

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

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