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位置: 首页> 品牌> Sigma-Aldrich> Anti-KDR/Flk-1/VEGFR2 Antibody

Anti-KDR/Flk-1/VEGFR2 Antibody

品牌
Sigma-Aldrich
货号
07-716-I
规格纯度
from rabbit, purified by affinity chromatography
价格
5688.25 *本价格含增值税费
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数量
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半岛bd体育手机客户端 名称:
Anti-KDR/Flk-1/VEGFR2 Antibody
Vascular endothelial growth factor receptor 2, VEGFR-2, Fetal liver kinase 1, FLK-1, Kinase NYK, Protein-tyrosine kinase receptor flk-1, CD309
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

The Flt gene family of receptor tyrosine kinases includes Flt-1, KDR/Flk-1, Flt-3, and Flt-4. They encode receptors for VEGF, characterized by seven Ig-loops within their extracellular domain and a split kinase domain within the cytoplasmic domain. VEGF is an important angiogenic factor of many solid tumors and is also involved in the differentiation of endothelial cells. Flt-1 (Fms-like tyrosine kinase, VEGF-R1) is expressed on endothelial cells and on the common precursors of endothelial and hematopoietic stem cells. KDR (Flk-1, VEGF-R2) is the principal receptor involved in VEGF signaling. KDR is expressed on endothelial cells and stimulates angiogenesis, but is also expressed on bone marrow cells, and is thought to play a role in driving the proliferation of most or all leukemic cells. Flt3 is a class III receptor tyrosine kinase that is closely related to c-Kit and c-Fms. It is expressed in primitive hematopoietic cells and its ligand exerts proliferative effects on these cells in co-operation with other cytokines. The VEGF receptors stimulate the Ras-MAP kinase pathway, suggesting that it signals as a conventional receptor tyrosine kinase.

免疫原

GST-tagged recombinant protein corresponding to the C-terminus of mouse KDR/Flk-1/VEGFR2.
Epitope: C-terminus

应用

Western Blotting Analysis: A 1:500 dilution from a representative lot detected KDR/Flk-1/VEGFR2 in 10 ?g of PAE cells transfected with CSF/VEGFR2 chimera.
Detect KDR/Flk-1/VEGFR2 using this rabbit polyclonal antibody, Anti-KDR/Flk-1/VEGFR2 Antibody validated for use in western blotting.
Research Category
Signaling
Research Sub Category
Developmental Signaling

质量

Evaluated by Western Blotting in HUVEC cell lysate.

Western Blotting Analysis: 1.0 ?g/mL of this antibody detected KDR/Flk-1/VEGFR2 in 10 ?g of HUVEC cell lysate.

目标描述

~230 kDa observed

联系

Replaces: 07-716

外形

Purified rabbit Polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Affinity purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss 32160702
NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 100
抗体形式 affinity isolated antibody
antibody product type primary antibodies
克隆 polyclonal
纯化方式 affinity chromatography
species reactivity mouse, human
technique(s) western blot: suitable
UniProt登记号 P35918
运输 wet ice

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

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