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Anti-JAK2 Antibody

品牌
Sigma-Aldrich
货号
06-255-I
包装型号
规格纯度
from rabbit
价格
4848.93 *本价格含增值税费
促销
服务
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数量
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半岛bd体育手机客户端 名称:
Anti-JAK2 Antibody
Tyrosine-protein kinase JAK2, JAK2, Janus kinase 2
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Tyrosine-protein kinase JAK2 (EC 2.7.10.2; UniProt Q62120; also known as JAK-2, Janus kinase 2) is encoded by the Jak2 (also known as Fd17) gene (Gene ID 16452) in murine species. JAK2 belongs to the family of non-receptor Janus tyrosine kinases that regulate a spectrum of cellular functions downstream of activated cytokine receptors in the lympho-hematopoietic system. Immunological stimuli, such as interferons and cytokines cause the recruitment of Stat transcription factors to cytokine receptor. Subsequent phosphorylation by receptor-associated JAK2 causes Stat dimerization, nuclear translocation, and Stat-mediated target genes transcription. The canonical JAK/Stat pathway is integral to maintaining a normal immune system by stimulating proliferation, differentiation, survival, and host resistance to pathogens. Altering JAK/Stat signaling to reduce immune cells cytokine responses represents an attractive target for anti-inflammatory therapies. Within the JAK2 kinase domain, there is a region that has considerable sequence homology to the regulatory region of the insulin receptor.

免疫原

Epitope: Residues 758-776
KLH-conjugated linear peptide corresponding to residues 758-776 of mouse JAK2.

应用

Research Category
Signaling
Research Sub Category
Developmental Signaling

质量

Evaluated by Western Blotting in RAW264.7 cell lysate.

Western Blotting Analysis: 0.5 ?g/mL of this antibody detected JAK2 in 10 ?g of RAW264.7 cell lysate.

目标描述

~130 kDa observed. Uncharacterized band(s) may appear in some lysates.

外形

Format: Purified
Protein A purified
Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

其他说明

Concentration: Please refer to lot specific datasheet.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss 32160702

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 100
抗体形式 purified antibody
antibody product type primary antibodies
克隆 polyclonal
species reactivity human, mouse, rat
technique(s) immunoprecipitation (IP): suitable
western blot: suitable
NCBI登记号 NP_001041642
UniProt登记号 Q62120
运输 wet ice

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

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