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Indatraline hydrochloride

品牌
Sigma-Aldrich
CAS
96850-13-4
货号
I119
规格纯度
solid
价格
2021.88 *本价格含增值税费
促销
服务
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  • 包邮
  • 增值税票
数量
- +
半岛bd体育手机客户端 名称:
96850-13-4
Indatraline hydrochloride
Lu 19-005
(±)- trans-3-(3,4-Dichlorophenyl)-N-methyl-1-indanamine hydrochloride
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

应用

Indatraline hydrochloride has been used:

  • as a competitive inhibitor of 3H-dopamine ([3H]DA) to study its effects on trans-activator of transcription (Tat) protein on cocaine-induced inhibition of uptake of [3H]DA
  • as a dopamine transport blocker to study its effects on trace amine-associated receptor 1 (TAAR1)-transfected mice cells
  • as a nonselective monoamine transport inhibitor to study its anti-angiogenic activities in glioblastoma multiforme (GBM)

包装

10, 25, 100 mg in glass bottle

生化/生理作用

Indatraline is a non-selective monoamine transport inhibitor. It inhibits the reuptake of neurotransmitters, such as serotonin, norepinephrine and dopamine. It exhibits anti-depressant and anti-angiogenic effects. Indatraline also plays a role in inducing autophagy.

特点和优势

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

法律信息

Sold with the permission of H. Lundbeck A/S.

基本信息

经验(实验)分子式 C16H15Cl2N · HCl
分子量 328.66
MDL编号 MFCD00083178
PubChem化学物质编号 24277939
NACRES NA.77

半岛bd体育手机客户端 性质

质量水平 100
形式 solid
颜色 white
溶解性 H2O: 2 mg/mL
储存温度 2-8℃
SMILES string Cl.CN[C@@H]1C[C@@H](c2ccc(Cl)c(Cl)c2)c3ccccc13
InChI 1S/C16H15Cl2N.ClH/c1-19-16-9-13(11-4-2-3-5-12(11)16)10-6-7-14(17)15(18)8-10;/h2-8,13,16,19H,9H2,1H3;1H/t13-,16+;/m0./s1
InChI key QICQDZXGZOVTEF-MELYUZJYSA-N
Gene Information human ... DRD1(1812), DRD2(1813), DRD3(1814), DRD4(1815), DRD5(1816), HTR1A(3350), HTR1B(3351), HTR1D(3352), HTR1E(3354), HTR1F(3355), HTR2A(3356), HTR2B(3357), HTR2C(3358), HTR3A(3359), HTR3B(9177), HTR3C(170572), HTR3D(200909), HTR3E(285242), HTR4(3360), HTR5A(3361), HTR5B(645694), HTR6(3362), HTR7(3363)

安全信息

象形图 GHS09
警示用语: Warning
危险声明 H400
预防措施声明 P273
危险分类 Aquatic Acute 1
储存分类代码 13 - Non Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable
个人防护装备 Gloves

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