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位置: 首页> 品牌> Sigma-Aldrich> Anti-NG2 Chondroitin Sulfate Proteoglycan Antibody, clone 132.38

Anti-NG2 Chondroitin Sulfate Proteoglycan Antibody, clone 132.38

品牌
Sigma-Aldrich
货号
MAB5384-I
规格纯度
clone 132.38, from mouse
价格
1415.25 *本价格含增值税费
促销
服务
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数量
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半岛bd体育手机客户端 名称:
Anti-NG2 Chondroitin Sulfate Proteoglycan Antibody, clone 132.38
Chondroitin sulfate proteoglycan 4, Chondroitin sulfate proteoglycan NG2, HSN tumor-specific antigen, NG2
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Chondroitin sulfate proteoglycan 4 (UniProt: Q00657; also known as Chondroitin sulfate proteoglycan NG2, HSN tumor-specific antigen) is encoded by the Cspg4 (also known as Ng2) gene (Gene ID: 81651) in rat. Chondroitin sulfate proteoglycan NG2 is a single-pass type I membrane protein that plays a role in cell proliferation and migration and stimulates endothelial cells motility during microvascular morphogenesis. It is present in neural cells and in extraneural tissues, especially in the developing mesenchyme. Its level of expression is highest on immature, proliferating cells and decreases when these cells begin to differentiate. It is found on the surfaces of an unusual class of glial cells within the developing and mature central nervous system that have the properties of oligodendrocyte precursor cells. It is a major chondroitin sulfate proteoglycan that is produced after spinal cord injury and is expressed by macrophages and oligodendrocyte progenitors. It is also reported to inhibit neurite outgrowth and growth cone collapse during axon regeneration. NG2 chondroitin sulfate proteoglycan is synthesized with a signal peptide (aa 1-29), which is subsequently cleaved off in the mature form. (Ref.: Jones, LL et al. (2002). J. Neurosci. 22(7):2792-2803).

特异性

Clone 132.38 is a mouse monoclonal antibody that detects Chondroitin sulfate proteoglycan 4 in rat brain tissue.

免疫原

HEK293 cells expressing a truncated integral membrane form of NG2 consisting of amino acids 1592-2222.

应用

Anti-NG2 Chondroitin Sulfate Proteoglycan, clone 132.38, Cat. No. MAB5384-I, is a highly specific mouse monoclonal antibody that targets Chondrin Sulfate Protoglycan 4 and has been tested for use in Immunofluorescence and Western Blotting.
Western Blotting Analysis: 1 ?g/mL from a representative lot detected NG2 Chondroitin Sulfate Proteoglycan in Rat E16 brain tissuel lysate.

Immunofluorescence Analysis: A 1:50 dilution from a representative lot detected NG2 Chondroitin Sulfate Proteoglycan in rat brain frozen sections, post-fixed in ethanol.

Research Category
Neuroscience

质量

Evaluated by Western Blotting in NIH/3T3 cell lysate.

Western Blotting Analysis: 1 ?g/mL of this antibody detected NG2 Chondroitin Sulfate Proteoglycan in NIH/3T3 cell lysate.

目标描述

~260 kDa observed. Uncharacterized bands may be observed in some lysate(s).

联系

Replaces: MAB5384 and 05-710

外形

Protein G purified
Format: Purified
Purified mouse monoclonal antibody IgG1 in buffer containing PBS, pH 7.2, containing 0.05% sodium azide.

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

其他说明

Concentration: Please refer to lot specific datasheet.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss 32160702

半岛bd体育手机客户端 性质

生物来源 mouse
抗体形式 purified immunoglobulin
antibody product type primary antibodies
克隆 132.38, monoclonal
species reactivity mouse, rat
包装 antibody small pack of 25 μg
technique(s) immunofluorescence: suitable
western blot: suitable
同位素/亚型 IgG1κ
NCBI登记号 NP_112284
UniProt登记号 Q00657

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 2
闪点(F) Not applicable
闪点(C) Not applicable

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