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Anti-Integrin α5β1 Antibody, clone BMA5

Anti-Integrin α5β1 Antibody, clone BMA5

品牌
Sigma-Aldrich
货号
MAB1984-I
规格纯度
culture supernatant, clone BMA5, from rat
价格
6190.47 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
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半岛bd体育手机客户端 名称:
Anti-Integrin α5β1 Antibody, clone BMA5
Integrin alpha-5, CD49 antigen-like family member E, Fibronectin receptor subunit alpha, Integrin alpha-F, VLA-5, CD49e, Integrin alpha-5 heavy chain, Integrin alpha-5 light chain, Integrin α5β1, Integrin beta-1, Fibronectin receptor subunit be
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Integrin alpha-5 (UniProt P11688; CD49 antigen-like family member E, CD49e, Fibronectin receptor subunit alpha, Integrin alpha-F, VLA-5) and Integrin beta-1 (UniProt P09055; CD29, Fibronectin receptor subunit beta, GpIIa, VLA-4 subunit beta) are encoded by the Itga5 (VLA5, Fnra; Gene ID 16402) and the Itgb1 (Fnrb; Gene ID 16412) gene, respectively, in murine species. The integrin family of cell adhesion receptors consists of at least 16 membrane-associated heterodimers, composed of an alpha and beta subunit that associate in a non-covalent manner. The structure and functional diversity of the integrin family are based upon the pairing abilities of the individual alpha and beta subunits. Key to these molecular interactions between the integrin receptors and their respective ligands is the recognition of the Arg-Gly-Asp (RGD) sequence, known to be present in the extracellular matrix components fibronectin, vitronectin, collagen, fibrinogen, and von Willebrand factor. The involvement of integrins in vascular proliferation, adhesion, and wound repair has been well documented. The adhesion receptor alphaVbeta1 is also known as VLA-5 (very late antigen-5) and the primary receptor for fibronectin. VLA-5 is reported to be involved many important physiological events, including angiogenesis, inflammation, neural crest development and cardiovascular morphogenesis.

免疫原

SSC-VII cells.

应用

This Anti-Integrin α5β1 Antibody, clone BMA5 is validated for use in Flow Cytometry, Immunoprecipitation, Affects Function for the detection of Integrin α5β1.
Immunoprecipitation Analysis: A representative lot immunoprecipitated integrin VLA-5 (αVβ1) complex from murine cells, including SSC-VII oral cavity cancer cells, B16F1 melanoma cells, and mast cells (CFTL-15 & MC/9, BMMCs) (Fehlner-Gardiner, C.C., et al. (1996). Differentiation. 60(5):317-325).
Affects Function: A representative lot suppressed β2GPI surface expression on RAW264.7 cells and attenuated cardiolipin-β2GPI (aCL/β2GPI) complex- and gelsolin-mediated cellular p38 and FAK phosphorylation (Bohgaki, M., et al. (2011). J. Cell. Mol. Med. 15(1):141-151).
Affects Function: A representative lot, when combined with anti-Integrin β3 antibody, greatly blocked EphA8-stimulated NIH/3T3 adhesion to fibronectin surface (Gu, C., and Park, S. (2001). Mol Cell Biol. 21(14):4579-4597).
Affects Function: A representative lot, when combined with anti-Integrin α4, clone PS/2 (Cat. No. CBL1304), greatly blocked PMA-stimulated adhesion of spleen T-cells from non-obese diabetic (NOD) mice to fibronectin-coated surface (Uniyal, S., et al. (1999). J. Autoimmun. 12(3):167-176).
Affects Function: A representative lot, when administered together with anti-Integrin α4, clone PS/2 (Cat. No. CBL1304) via intraperitoneal injection, greatly reduced pancreas islet leukocyte infiltration among non-obese diabetic (NOD) mice following diabetes onset induction by cyclophosphamide injection (Uniyal, S., et al. (1999). J. Autoimmun. 12(3):167-176).
Affects Function: A representative lot blocked integrin αVβ1-mediated adhesion of murine bone marrow-derived mast cells (BMMCs) to fibronectin-coated surface upon PMA stimulation (Fehlner-Gardiner, C.C., et al. (1996). Differentiation. 60(5):317-325).
Flow Cytometry Analysis: A representative lot detected integrin VLA-5 (αVβ1) immunoreactivity on the surface of murine peritoneal macrophages and peripheral blood monocytes (Kapetanovic, R., et al. (2011). Am. J. Physiol. Cell Physiol. 300(4):C850-859).
Flow Cytometry Analysis: A representative lot detected integrin VLA-5 (αVβ1) immunoreactivity on the surface of murine embryonic fibroblasts (Gupta, S.K., and Vlahakis, N.E. (2009). J. Cell Sci. 122(Pt 12):2043-2054).
Flow Cytometry Analysis: A representative lot detected integrin VLA-5 (αVβ1) immunoreactivity on the surface of CD4+ or CD8+ T-cells from peripheral blood and spleen of non-obese diabetic (NOD) mice (Uniyal, S., et al. (1999). J. Autoimmun. 12(3):167-176).
Flow Cytometry Analysis: A representative lot detected integrin VLA-5 (αVβ1) immunoreactivity on the surface of murine bone marrow-derived mast cells (BMMCs) (Fehlner-Gardiner, C.C., et al. (1996). Differentiation. 60(5):317-325).

质量

Evaluated by Flow Cytometry in NIH/3T3 cells.

Flow Cytometry Analysis: 100 ?L of 1:200 dilution from this antibody detected Integrin α5β1 in NIH/3T3 cells.

目标描述

115 kDa calculated

联系

Replaces: MAB1984

外形

Rat monoclonal IgG2bκ antibody in tissue culture supernatant without preservatives.
Unpurified

其他说明

Concentration: Please refer to lot specific datasheet.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss 32160702
NACRES NA.41

半岛bd体育手机客户端 性质

质量水平 100
生物来源 rat
抗体形式 culture supernatant
antibody product type primary antibodies
克隆 BMA5, monoclonal
species reactivity mouse
technique(s) flow cytometry: suitable
immunoprecipitation (IP): suitable
同位素/亚型 IgG2bκ
NCBI登记号 NP_034707
NP_034708
UniProt登记号 P09055
P11688
运输 dry ice

安全信息

储存分类代码 10 - Combustible liquids
WGK WGK 1

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