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位置: 首页> 品牌> Sigma-Aldrich> Anti-PNMT Antibody

Anti-PNMT Antibody

品牌
Sigma-Aldrich
货号
AB110-I
规格纯度
from rabbit, purified by affinity chromatography
价格
5854.74 *本价格含增值税费
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数量
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半岛bd体育手机客户端 名称:
Anti-PNMT Antibody
Phosphatidylethanolamine N-methyltransferase, PEAMT, PEMT, PEMT2
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

PNMT, also known as Phosphatidylethanolamine N-methyltransferase, or PEMT, PEAMT, or PEMT2, and encoded by the gene PEMT/PEMPT/PNMT, catalyzes three sequential methylation reactions of phosphatidylethanolamine to produce phosphatidylcholine a major constituent of cell membranes and a primary pulmonary surfactant. PNMT/PEMT is localized to the endoplasmic reticulum membrane as well as the mitochondrial membranes. PNMT/PEMT is widely expressed, and has the highest activity in the mitochondria. The conversion of phosphatidylethanolamine to phosphatidylcholine by sequential methylation via PNMT/PEMT occurs in the liver. A different pathway for phosphatidylcholine production starting from choline also is present in cells but it does not involve PNMT/PEMT enzyme. Mutations in PNMT/PEMT protein are associated with nonalcoholic fatty liver disease (NAFLD).

免疫原

KLH-conjugated linear peptide corresponding to the C-terminus of human PNMT.
Epitope: C-terminus

应用

Immunohistochemistry Analysis: A 1:500 dilution and a 1:2,000 dilution from a representative lot detected PNMT in human adrenal gland and testis tissues, respectively.
Research Sub Category
Signaling Neuroscience
Research Category
Neuroscience
Anti-PNMT Antibody detects level of PNMT & has been published & validated for use in PNMT.

质量

Evaluated by Western Blotting in human liver tissue lysate.

Western Blotting Analysis: 2 ?g/mL of this antibody detected PNMT in 10 ?g of human liver tissue lysate.

目标描述

~17 kDa observed. As isoform of PNMT has been observed between 15-20 kDa (Cui, Z., et al. (1993). J Biol. Chem. 268(22):16655-16663.).

联系

Replaces: AB110

外形

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Affinity purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss 32160702
NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 100
抗体形式 affinity isolated antibody
antibody product type primary antibodies
克隆 polyclonal
纯化方式 affinity chromatography
species reactivity human
technique(s) immunohistochemistry: suitable
western blot: suitable
NCBI登记号 NP_001254480
UniProt登记号 Q9UBM1
运输 wet ice

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

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