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Trimethyl(trifluoromethyl)silane solution

三甲基(三氟甲基)硅烷 溶液

品牌
Sigma-Aldrich
CAS
81290-20-2
货号
91862
规格纯度
2 M in THF
价格
334.63 *本价格含增值税费
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半岛bd体育手机客户端 名称:
81290-20-2
Trimethyl(trifluoromethyl)silane solution
(Trifluoromethyl)trimethylsilane
Ruppert′s reagent
Trifluoromethyltrimethylsilane
Ruppert-Prakash Reagent
TFMTMS
三甲基(三氟甲基)硅烷 溶液
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Trimethyl(trifluoromethyl)silane (TMSCF3) is also called as Ruppert-Prakash fluorination reagent. It is extensively used for the synthesis of trifluoromethyl-containing compounds.

应用

Reactant for:

  • Silver-mediated C-H trifluoromethylation of arenes
  • Preparation of trifluoromethyl ketone analog of L-arginine having contrasting inhibitory activity against human arginase I and histone deacetylase 8
  • Organocatalyzed regio- and enantioselective allylic trifluoromethylation of Morita-Baylis-Hillman adducts
  • Palladium-catalyzed oxidative trifluoromethylation of indoles
  • Preparation of 5-HT1A antagonists

  • Used as difluorocarbene source

TMSCF 3can be used as a reagent for:
  • Conversion of aromatic aldehydes to difluoromethylated products.
  • C-H trifluoromethylation of arenes, terminal alkynes, tertiary amines, heteroarenes, allylic, and terminal alkenes using metal catalyst or metal free oxidative trifluoromethylation reaction.

It can also be used in trifluoromethylation of:
  • Non-activated aldimines.
  • Heterocumulenes.
  • Azomethine imines.

包装

10, 50 mL in glass bottle

基本信息

线性分子式 (CH3)3SiCF3
分子量 142.19
Beilstein 4241868
MDL编号 MFCD00145454
PubChem化学物质编号 57653455
NACRES NA.22

半岛bd体育手机客户端 性质

形式 liquid
质量水平 100
reaction suitability reaction type: C-C Bond Formation
浓度 2 M in THF
折射率 n 20/D 1.386
密度 0.91 g/mL at 20 ℃
SMILES string C[Si](C)(C)C(F)(F)F
InChI 1S/C4H9F3Si/c1-8(2,3)4(5,6)7/h1-3H3
InChI key MWKJTNBSKNUMFN-UHFFFAOYSA-N

安全信息

象形图 GHS02GHS07GHS08
警示用语: Danger
危险声明 H225 - H302 - H319 - H335 - H351
预防措施声明 P210 - P280 - P301 + P312 + P330 - P305 + P351 + P338 - P370 + P378 - P403 + P235
危险分类 Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3
靶器官 Respiratory system
补充剂危害 EUH019
储存分类代码 3 - Flammable liquids
WGK WGK 3
闪点(F) 1.4 °F
闪点(C) -17 ℃
个人防护装备 Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

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