Anti-Histone Deacetylase 7 (HDAC7) (YS-19) antibody produced in rabbit

半岛bd体育手机客户端 说明

一般描述

Histone deacetylases (HDACs) are competing enzymes, belonging to histone deacetylase family. There are two classes of HDACs with six to seven different types of HDACs proteins. HDAC1, HDAC2 and HDAC3 belong to Class I HDACs and HDAC4, HDAC6, and HDAC7 belong to Class II HDACs. Class I HDACs consists of a single deacetylase domain at the N-termini and diversified C-terminal regions, while Class II contains a deacetylase domain at C-terminal position. HDAC7 is predominantly found in the cell nucleus and slightly in cytoplasm. HDAC7 shuttles between these two regions and this is controlled by 14-3-3 protein and calmodulin-dependent kinase I (CaMKI)

免疫原

synthetic peptide corresponding to amino acids 137-155 of mouse HDAC7 with N-terminal added lysine, conjugated to KLH.

应用

Anti-Histone Deacetylase 7 (HDAC7) (YS-19) antibody produced in rabbit has been used in:

• immunoblotting
• immunoprecipitation
• antibody microarray

包装

200 μL in glass bottle

生化/生理作用

HDAC7 belongs to class II of HDAC family and combines with MEF2 group of transcription factors, which is facilitated by theN-terminal domain of HDAC7. This binding blocks the transcriptional activity and prevents myogenesis. They are involved in development and differentiation processes in various tissues such as skeletal, cardiac, and smooth muscle, the bone, the immune system, the vascular system, and the brain. These signal-dependent co-repressors phosporylate at the regulatory N-terminal domain resulting in nuclear export.

外形

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号	MFCD04040365
NACRES	NA.41

半岛bd体育手机客户端 性质

生物来源	rabbit
质量水平	200
偶联物	unconjugated
抗体形式	affinity isolated antibody
antibody product type	primary antibodies
克隆	polyclonal
形式	buffered aqueous solution
分子量	antigen ~105 kDa
species reactivity	mouse, rat, human
technique(s)	immunoprecipitation (IP): 1.5-1.8 μg using RIPA extract of 293T cells expressing recombinant human HDAC7 microarray: suitable western blot: 1:2,000 using whole extracts of mouse NIH-3T3 cells western blot: 1:500 using whole extracts of rat PC12 cells
UniProt登记号	Q8WUI4
运输	dry ice
储存温度	?20℃
Gene Information	human ... HDAC7(51564) mouse ... Hdac7(56233) rat ... Hdac7a(84582)

安全信息

储存分类代码	12 - Non Combustible Liquids
WGK	nwg
闪点(F)	Not applicable
闪点(C)	Not applicable