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Histone H1 human

品牌
Sigma-Aldrich
CAS
1523001-32-2
货号
H1917
包装型号
规格纯度
价格
1082.01 *本价格含增值税费
促销
服务
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数量
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半岛bd体育手机客户端 名称:
1523001-32-2
Histone H1 human
Histone, Human
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Histone H1 is part of high-order chromatin structure and is a linker protein associated with nucleosome core particle. Histone H1 is mapped to human chromosome 6. Histone H1 exists in different isoforms. Histone H1 comprises of N-terminal hydrophobic rich region, central globular domain and a C-terminal with intrinsically disordered regions.

生化/生理作用

The C-terminal regions of histone H1 is essential for binding to chromatin. The placement of H1 is necessary for nucleosome positioning. Histone H1 maintains chromosome architecture and stabilises compaction of nucleosomes during interphase. H1-null mutants display increased rate of chromatin aberration and growth defects. Histone H1 modulates embryogenesis and DNA repair. The H1 histone undergoes posttranslational modification including phosphorylation, methylation and acetylation, each of which carry out different physiological functions. Histone H1 and its variants contribute to the pathogenesis in cancer, Alzheimer′s disease, male infertility and immunity related disorders.

外形

Supplied as 1 mg/mL in 20 mM NaPO4, pH 7.0, 0.3 M NaCl, 1 mM EDTA, and 1 mM DTT.

基本信息

NACRES NA.25

半岛bd体育手机客户端 性质

质量水平 200
生物来源 human
重组 expressed inE. coli
形式 liquid
浓度 1 mg/mL
UniProt登记号 P07305
运输 wet ice
储存温度 ?20℃
Gene Information human ... H1.0(3005)

安全信息

象形图 GHS07
警示用语: Warning
危险声明 H319
预防措施声明 P264 - P280 - P305 + P351 + P338 - P337 + P313
危险分类 Eye Irrit. 2
储存分类代码 12 - Non Combustible Liquids
WGK WGK 2
闪点(F) Not applicable
闪点(C) Not applicable

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