Hepatitis C virus core antigen

半岛bd体育手机客户端 说明

一般描述

Hepatitis C virus core antigen (HCV-cAg) is a well-preserved antigenic protein of the internal capsid.
Hepatitis C virus glycoprotein 1 (HCVgp1), also referred to as polyprotein, is crucial for the induction of double-membrane vesicles, sites of HCV RNA amplification. The amino terminal of polyprotein contains the structural proteins core, envelope protein 1 (E1) and E2. The proteolytic cleavage of polyprotein results in the formation of 10 mature viral proteins which are needed for viral replication and assembly.
amino acids 2-192 of HCV polyprotein

特异性

Reacts strongly with human HCV positive serum.

应用

Hepatitis core antigen (HCA) has been used as an analyte in enzyme-linked immunosorbent assay (ELISA) to study the mechanism of bovine serum albumin (BSA) blocking in common ELISA protocols.

生化/生理作用

Hepatitis C virus core antigen (HCV-cAg) may be a less expensive way to diagnose active hepatitis C virus (HCV) infection in the hemodialysis (HD) population.
Positive control for HCV antibodies.

其他说明

HCV core antigen [2-192]-Galactosidase-tagged at the N-terminus.

外形

Solution in 8 M Urea, 20 mM Tris-HCl, pH 8.0, 10 mM 2-mercaptoethanol.

基本信息

MDL编号	MFCD02264926
NACRES	NA.32

半岛bd体育手机客户端 性质

质量水平	200
重组	expressed inE. coli
测定	≥95% (SDS-PAGE)
分子量	22 kDa (plus 114 kDa galactosidse)
浓度	~1 mg/mL
UniProt登记号	G9G988 L7S4V3
运输	dry ice
储存温度	?20℃
Gene Information	hepatitis C virus ... HCVgp1(951475) human ... HBVgp4(944568)

安全信息

储存分类代码	12 - Non Combustible Liquids
WGK	WGK 1
闪点(F)	Not applicable
闪点(C)	Not applicable