Hemopexin from human plasma

半岛bd体育手机客户端 说明

一般描述

Hemopexin (HPX) is produced by cells of the central nervous system. It is a 60 kDa serum glycoprotein.

应用

Hemopexin from human plasma has been usedS. aureussurface colonization assay. It has also been used to stimulate mixed lymphocyte cells to determine the biomarkers in acute rejection.

包装

500 μg in poly bottle

生化/生理作用

Hemopexin is an acute-phase protein that plays a major protective role against oxidative stress through its heme-scavenging activities. Hemopexin binds heme with high affinity and is critical for recycling the iron bound to heme molecules and for protecting against heme-induced cellular damage. Free heme, when released or lost from proteins like hemoglobin, can catalyze the formation of reactive oxygen species. Heme is lipophilic and interchelates into lipid membranes and participate in the formation of highly-toxic hydroxyl radicals. Hemopexin may also protect against the heme-mediated oxidation of LDL cholesterol.

Hemopexin may also serve an anti-inflammatory role via the negative regulation of IL-6 and TNF-α secretion by activated macrophages.

外形

Lyophilized powder containing sodium phosphate, NaCl, and KCl, pH 7.4

半岛bd体育手机客户端 性质

质量水平	100
生物来源	human plasma
测定	≥95% (SDS-PAGE)
形式	lyophilized powder
分子量	~57 kDa
technique(s)	microbiological culture: suitable
NCBI登记号	NP_000604
储存温度	?20℃
Gene Information	human ... HPX(3263)

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable