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Anti-Hepatocyte Growth Factor Receptor (c-Met) antibody produced in goat

品牌
Sigma-Aldrich
货号
H9786
规格纯度
affinity isolated antibody, lyophilized powder
价格
4915.81 *本价格含增值税费
促销
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半岛bd体育手机客户端 名称:
Anti-Hepatocyte Growth Factor Receptor (c-Met) antibody produced in goat
Anti-HGF Receptor
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

The antibody neutralizes receptor-ligand interaction. At 0.5-2 μg/mL the antibody will block 50% of the binding of 5 ng/mL recombinant human HGF to 0.1 μg immobilized recombinant human HGF R/c-MET Fc chimera. >90% of the binding will be blocked by 10 μg/mL of the antibody.

免疫原

purified recombinant human hepatocyte growth factor receptor extracellular domain expressed in mouse NSO cells.

应用

Anti-Hepatocyte Growth Factor Receptor (c-Met) antibody produced in goat was used to block c-Met in HeLa cells.

生化/生理作用

Hepatocyte Growth Factor (HGF) is a multifunctional, heparin-binding factor that stimulates the proliferation of liver cells. The cellular effects of HGF are mediated by its receptor, c-Met, that leads to significant activation of ERK, Src/FAK, STAT3 and PI3K signaling. Various functions of the HGF/c-Met signaling include proliferation, cell survival, motility and adhesion and tissue regeneration. Apart from liver, HGF also mediates regeneration of kidney, lung and gastro-intestines.

外形

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing carbohydrates.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号 MFCD03791597
NACRES NA.41

半岛bd体育手机客户端 性质

质量水平 100
生物来源 goat
偶联物 unconjugated
抗体形式 affinity isolated antibody
antibody product type primary antibodies
克隆 polyclonal
形式 lyophilized powder
species reactivity human
technique(s) flow cytometry: suitable
immunohistochemistry: 5-15 μg/mL
western blot: 0.1-0.2 μg/mL
杂质 endotoxin, tested
UniProt登记号 P08581
储存温度 ?20℃
Gene Information human ... MET(4233)
mouse ... Met(17295)

安全信息

储存分类代码 13 - Non Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable
个人防护装备 Eyeshields, Gloves, type N95 (US)

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