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位置: 首页> 品牌> Sigma-Aldrich> Nα-甲基组胺 二盐酸盐

Nα-Methylhistamine dihydrochloride

Nα-甲基组胺 二盐酸盐

品牌
Sigma-Aldrich
CAS
16503-22-3
货号
H5914
包装型号
规格纯度
solid
价格
1989.21 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
- +
半岛bd体育手机客户端 名称:
16503-22-3
N α-Methylhistamine dihydrochloride
NAMH dihydrochloride
N-Methyl-1H-imidazole-4-ethanamine dihydrochloride
N α-甲基组胺 二盐酸盐
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

包装

10, 50 mg in glass bottle

生化/生理作用

Nα-Methylhistamine dihydrochloride helps in removing or decreasing the headache in migraine prophylaxis. It is highly effective than histamine in inducing cyclic adenosine 3′,5′-monophosphate (cAMP) synthesis.
Production of N-alpha-methyl-histamine (NAMH), a histamine H(3) receptor (H3R) agonist, is promoted inHelicobacter pyloriinfected human gastric mucosa. NAMH acts directly on histamine H(2) receptors (H2Rs) in animals to stimulate acid secretion and to be a H2R agonist. NAMH dose dependently stimulated cAMP productions in CHO-H2R cells. This production was inhibited by famotidine but not by thioperamide. Control CHO cells were unresponsive to either histamine or NAMH. In addition, the effect of NAMH, in terms of cAMP production in CHO-H2R cells, was more potent than that of histamine-that is, with a lower EC50concentration and higher maximal cAMP production. Both NAMH and histamine, but not R-alpha-methyl-histamine, effectively inhibited [(3)H] tiotidine binding to CHO-H2R cells. These results confirm that NAMH, which is produced in the gastric mucosa by H pylori, is a potent H2R agonist as well as a H3R agonist.

特点和优势

This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

基本信息

经验(实验)分子式 C6H11N3· 2HCl
分子量 198.09
MDL编号 MFCD00134838
PubChem化学物质编号 24724503
NACRES NA.77

半岛bd体育手机客户端 性质

质量水平 100
测定 (The product is pure based on elemental analysis results, NMR and MS spectra.)
形式 solid
颜色 white
溶解性 H2O: >20 mg/mL
储存温度 2-8℃
SMILES string Cl[H].Cl[H].CNCCc1c[nH]cn1
InChI 1S/C6H11N3.2ClH/c1-7-3-2-6-4-8-5-9-6;;/h4-5,7H,2-3H2,1H3,(H,8,9);2*1H
InChI key AYUQICXJAMPXPF-UHFFFAOYSA-N

安全信息

象形图 GHS05GHS07
警示用语: Danger
危险声明 H302 - H315 - H318 - H335
预防措施声明 P280 - P301 + P312 + P330 - P302 + P352 - P305 + P351 + P338 + P310
危险分类 Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
靶器官 Respiratory system
储存分类代码 11 - Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable
个人防护装备 dust mask type N95 (US), Eyeshields, Gloves

Sigma-Aldrich

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